2025年3月30日 · GNAQ (G Protein Subunit Alpha Q) is a Protein Coding gene. Diseases associated with GNAQ include Sturge-Weber Syndrome and Capillary Malformations, Congenital. Among its related pathways are Thromboxane signalling through TP receptor and Development Angiotensin activation of ERK.

Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex.

The GNAQ gene provides instructions for making a protein called guanine nucleotide-binding protein G (q) subunit alpha (Gαq). The Gαq protein is part of a group of proteins called the trimeric G protein complex. This complex attaches (binds) …

GNAQ and GNA11 Genes: A Comprehensive Review on Oncogenesis, Prognosis and Therapeutic Opportunities in Uveal Melanoma. The GNAQ and GNA11 genes are mutated in almost 80-90% of uveal melanomas in a mutually exclusive pattern.

2024年9月3日 · GNAQ（Guanine Nucleotide-Binding Protein, Q Polypeptide）是G蛋白家族中的一员，作为Gq蛋白的α亚基，GNAQ 在细胞内信号传导中发挥着重要作用。 GNAQ蛋白由约359个氨基酸组成，其结构可以分为多个关键功能域，每个功能域

GNAQ and GNA11 genes encode protein members of the q class of G-protein alpha subunits involved in mediating signals between G-protein coupled receptors (GPCRs) and downstream effectors . Both genes have mainly been considered as driver genes in carcinogenesis, as they lead to constitutive activation of GPCR signalling.

该基因座编码鸟嘌呤核苷酸结合蛋白。 编码的蛋白质是 Gq 类中的一个 alpha 亚基，将一个七跨膜结构域受体与磷脂酶 C-beta 的激活结合起来。 该位点的突变与血小板活化和聚集的问题有关。 2 号染色体上存在一个相关的假基因。 [RefSeq 提供，2010 年 11 月] This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta.

GNAQ基因所编码的蛋白属于鸟嘌呤核苷酸结合蛋白（G蛋白）的家族，GNAQ与GNA11形成的复合物为G蛋白α亚基，这两个基因调控细胞分裂，增强MEK（有丝分裂原活化蛋白激酶的激酶）蛋白活性，在80%的葡萄膜黑色素瘤病人中发现GNA11和GNAQ基因的突变，其机制为基因突变导致MEK的异常激活，目前正在开发MEK抑制剂作为针对GNA11与GNAQ突变的肿瘤。 请 登录 后查看 GNAQ基因突变 详细信息。 这个位点编码鸟嘌呤核苷酸结合蛋白。 编码蛋白是GQ类的α亚单 …

Gene ID: 2776, updated on 8-Feb-2025. This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation.

Expression of G protein αq Subunit is Decreased in Lymphocytes from Patients with Rheumatoid Arthritis and is Correlated with Disease Activity. 这个基因座编码一个鸟嘌呤核苷酸结合蛋白。 编码的蛋白质是Gq类的α亚单位，将一个七跨膜域受体与磷酸脂酶C-β的激活相结合。 这个基因座的突变与血小板激活和聚集问题有关。 在染色体2上有一个相关的假基因。 [由RefSeq，2010年11月 …