AMPARs are composed of four types of subunits encoded by different genes, designated as GRIA1 (GluA1 or GluR1), GRIA2 (GluA2 or GluR2), GRIA3 (GluA3 or GluR3), and GRIA4 …

2023年9月13日 · Here we determine and characterize cryo-electron microscopy structures of the GluA1 homotetramer, fully occupied with TARPγ3 auxiliary subunits (GluA1/γ3). The gating …

A decrease in the total cell AMPA receptor currents and phosphorylation of serine845 of GluA1 is observed in chronic drug addiction. Increased expression of GluA1 causes pain and is …

In particular, several lines of evidence suggest that reversible phosphorylation of AMPAR subunit glutamate receptor 1 (GluR1, also referred to as GluA1 or GluR-A) plays a role in long-term …

2020年11月20日 · In this study, we report the first identification of IRES activity in GluA1 mRNA, which is regulated by BDNF stimulation in hippocampal neurons. We also find that the RNA …

突触后谷氨酸门控离子通道允许带正电荷的离子进入突触后细胞，并能进一步被分为AMPA（a-氨基-3-羟基-5-甲基-4-异唑丙酸）受体或NMDA（N-甲基-D-天冬氨酸）受体。 AMPA和 NMDA …

2022年3月14日 · We found that virally induced reduction of GluA1 across multiple hippocampal subfields impaired spatial working memory. Transgene-mediated ablation of GluA1 from …

2021年11月15日 · Gria1 encodes the GluA1 (also known as GluR-A or GluR1) subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype of glutamate receptors. …

Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) plays a key role in altering excitatory synaptic transmission in the CNS. Interestingly, the regulatory …

AMPAR assemblies are complex signaling machines that function as homo- or heterotetramers built from combinations of four core subunits, GluA1–4. As each subunit differs in its …