Glioblastoma, IDH-wildtype | Radiology Reference Article - Radiopaedia.org
2024年10月28日 · The original term glioblastoma multiforme was coined in 1926 by Percival Bailey and Harvey Cushing; the suffix multiforme was given to describe the various appearances of hemorrhage, necrosis, and cysts.
Pathology Outlines - Glioblastoma, IDH wild type
2022年7月27日 · A primitive neuronal component in glioblastoma can be diagnosed by identifying a morphologically distinct area with high cellularity, high mitotic activity, loss of expression of glial markers and expression of neuronal markers such as synaptophysin.
Glioblastoma multiforme – an overview - PMC
Although the biology of glioblastoma multiforme has recently been widely investigated, the studies summarizing the knowledge of its development and treatment are still not sufficient in terms of comprehensive brain tumor analysis.
On the Concepts and History of Glioblastoma Multiforme - Morphology …
2018年3月1日 · With the introduction of molecular and genetic tests the true multifomity of GBM has been established, with different genotypes bearing the same histomorphological and IHC picture, as well as some of the aspects of gliomagenesis.
Glioblastoma multiforme: morphology and biology - PubMed
Glioblastoma multiforme, representing about 50% of all gliomas, encompasses a group of intrinsic tumours of the brain in later years (age peak around 50 years), the morphological hallmarks of which are an ensemble of variations in tumour cell and …
On the origin and development of glioblastoma: multifaceted …
2023年6月24日 · Recent studies have led to the hypothesis that glioblastoma arises from neural stem cells and glial precursor cells and that cell lineage constitutes a key determinant of the glioblastoma molecular subtype.
Glioblastomas: Molecular Diagnosis and Pathology - IntechOpen
2022年7月8日 · At the molecular level and clinical, GBM has at least two types, primary and secondary. Each has a different tumorigenesis and clinical presentation. In this chapter, some major molecular biomarkers and diagnostic hallmarks of GBM will be reviewed and discussed.
Molecular Mechanisms of Glioma Cell Motility - Glioblastoma
2017年9月27日 · Glioblastoma (GBM), the most malignant brain tumor, has a complex biology, and despite decades of research, much is still unknown. GBM separates itself from lower grade gliomas by exhibiting central necrosis and microvascular proliferation. It is characterized by a rapid and highly infiltrative growth.
Glioblastoma multiforme: Morphology and biology | Acta …
Glioblastoma multiforme, representing about 50% of all gliomas, encompasses a group of intrinsic tumours of the brain in later years (age peak around 50 years), the morphological hallmarks of which are an ensemble of variations in tumour cell and …
Cell biology of glioblastoma multiforme: from basic science to ...
2018年1月31日 · GBM has an extremely wide set of alterations, both genetic and epigenetic, which yield a great number of mutation subgroups, some of which have an established role in independent patient survival and treatment response.