Science:抑制成纤维细胞Engrailed-1表达实现无痕化愈合 - 知乎
前期来自 斯坦福大学医学院的研究人员 发现，小鼠背部的真皮中至少包含两种不同的成纤维细胞谱系:En1（Engrailed-1）阴性成纤维细胞 (ENFs)和En1阳性成纤维细胞 (EPFs)。
The impact of the mesoprefrontal dopaminergic system on the …
2024年7月4日 · In Gli2 -cKO mice, mDA progenitors that give rise to mDA in the medial ventral tegmental area are severely reduced and mesoprefrontal DA projections fail to form. In …
Sonic hedgehog regulates Gli activator and repressor functions …
2006年5月1日 · We have discovered that Gli2A-mediated Shh signaling sequentially induces ventral neurons along the medial to lateral axis, and only before midgestation. Unlike in the …
[En1 promotes cell proliferation and migration via Hedgehog
2024年2月23日 · Real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) was used to detect the expressions of En1, glioma-associated oncogene family zinc finger 1 …
The level of sonic hedgehog signaling regulates the complexity of ...
2006年5月1日 · To determine whether Gli1 contributes activator function in Gli2-En1 cko mutants that is responsible for the low level of GCP proliferation and foliation present in Gli2-En1 cko …
转录因子En1通过调控Hedgehog信号通路促进食管鳞状细胞癌细胞 …
2025年3月11日 · 采用实时荧光定量聚合酶链反应（RT-qPCR）检测细胞中En1及Hedgehog通路主要调控因子胶质瘤相关癌基因家族锌指1（GLI1）、GLI2和平滑蛋白（SMO）的表达。
GLI1/GLI2 functional interplay is required to control …
2020年9月18日 · The Hedgehog-regulated transcription factors GLI1 and GLI2 play overlapping roles in development and disease; however, the mechanisms underlying their interplay remain …
Gli Proteins: Regulation in Development and Cancer - PMC
Gli proteins are members of the family of Kruppel-like factors with highly conserved Zn finger DNA-binding domains. In mammals, they are represented by three proteins: Gli1, Gli2 and …
GLI2 Gene - GeneCards | GLI2 Protein | GLI2 Antibody
2024年12月25日 · GLI2 (GLI Family Zinc Finger 2) is a Protein Coding gene. Diseases associated with GLI2 include Culler-Jones Syndrome and Holoprosencephaly 9. Among its related …
转录因子En1通过调控Hedgehog信号通路促进食管鳞状细胞癌细胞 …
2024年3月3日 · 采用实时荧光定量聚合酶链反应（RT-qPCR）检测细胞中En1及Hedgehog通路主要调控因子胶质瘤相关癌基因家族锌指1（GLI1）、GLI2和平滑蛋白（SMO）的表达。