Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from human glioblastoma cells. [5]

2025年3月30日 · GLI1 (GLI Family Zinc Finger 1) is a Protein Coding gene. Diseases associated with GLI1 include Polydactyly, Preaxial I and Polydactyly, Postaxial, Type A8. Among its …

GLI1 is typically not expressed in Hh-off cells, but when the signal is perpetuated by GLI2/3, in their active forms, it can induce the expression of GLI1 to amplify the effects of Hh signaling …

GLI1 regulates the neuropilin-2/alpha6beta1 integrin based autocrine pathway that contributes to breast cancer initiation. Gli1 deletion prevents Helicobacter-induced gastric metaplasia and …

GLI1 is a transcriptional effector at the terminal end of the Hedgehog signaling (Hh) pathway and is tightly regulated during embryonic development and tissue patterning/differentiation. GLI1 …

2023年11月1日 · Here, we find that a population of MuSCs, marked by Gli1 expression, is required for muscle regeneration. The Gli1 + MuSC population displays advantages in …

2024年9月19日 · GLI1蛋白是Hedgehog（Hh）信号通路的关键转录因子之一，负责调控细胞增殖、 分化以及组织发育中的基因表达。 GLI1在多种生物过程中发挥重要作用，尤其是在

GLI1是该通路中最重要转录因子之一，其异常活化与纤维化修复、肿瘤的发生发展与侵袭转移、肿瘤耐药和预后等密切相关。 本文就GLI1与肿瘤发生与侵袭转移作用机制进行综述。 哺乳动 …

2024年12月31日 · GLI1是这个通路中的一个关键转录因子，能够将信号从细胞表面传递到细胞核内，从而调控特定基因的表达。 尽管GLI1基因在正常发育中起到重要作用，但其异常表达或 …

GLI1 is one of three transcription factors (GLI1, GLI2 and GLI3) that mediate the Hedgehog signal transduction pathway and play important roles in normal development. GLI1 and GLI2 form a …