In biology, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and usually assumed to be related to biological function of the macromolecule. For example, an N -glycosylation site motif can be defined as Asn, followed by anything but Pro, followed by either Ser or Thr, followed by anything but Pro residue.

Motif并不局限于基因组DNA序列还是RNA序列，甚至蛋白质序列也可以提取出相应的motif。 通过序列信息的解析，我们可以解析生物学过程中的密码。 当某一个大类的序列中，大量重复出现相同的序列结构的时候，就可能存在探索它意义的价值。

2024年6月20日 · Motif分析是一种在生物信息学和计算生物学中广泛应用的技术，用于识别DNA、RNA或蛋白质序列中具有生物学功能的短保守序列模式（motif）。 这些motif通常与特定的生物学功能相关，如DNA中的转录因子结合位点、RNA中的剪接位点或蛋白质中的功能结构域。

motif 是一段重复出现在基因序列上的一段片段，通常具有高度重复的碱基序列，是 转录因子 或者 DNA结合蛋白 识别并结合的锚定点，就像之前说的，一个DNA结合蛋白可能对应多个motif，motif也会对应多个蛋白，但是大体上结合的信息，通过现在高通量的计算方式，是可以找到规律的，而JASPAR正是收录了这些信息。 JASPAR是一个免费公开的转录因子数据库，收集转录因子与DNA结合位点以及结合方式，共收集了脊椎动物、植物、昆虫、线虫、真菌和尾索动物 …

The gene sets can be downloaded as NCBI (Entrez) Gene Identifiers or HUGO (HGNC) Gene Symbols. There are also JSON bundles containing the Human gene sets using HUGO (HGNC) Gene Symbols along with some useful metadata.

Sequence motifs are short, recurring patterns in DNA that are presumed to have a biological function. Often they indicate sequence-specific binding sites for proteins such as nucleases and...

The MotifMap system provides comprehensive maps of candidate regulatory elements encoded in the genomes of model species using databases of transcription factor binding motifs, refined genome alignments, and a comparative genomic statistical approach- Bayesian Branch …

4 天之前 · The HGNC is a resource for approved human gene nomenclature containing ~42000 gene symbols and names and 1300+ gene families and sets

Gene symbol：基因通用名称，根据来源分为 offical symbol 和 loc symbol; official symbol 是由HGNC组织提供的基因通用名称；如果基因暂无official symbol，就在Entrez ID的前面添加LOC前缀作为其symbol, 比如LOC100653049

DISCOVER YOUR OWN MOTIFS: After you have discovered similar sequences but the motif searching tools have failed to recognize your group of proteins you can use the following tools to create a list of potential motifs. The MEME Suite-Motif-based sequence analysis tools (National Biomedical Computation Resource, U.S.A.). N.B.