Protein Wnt-5a is a protein that in humans is encoded by the WNT5A gene. [5][6] The WNT gene family consists of structurally related genes that encode secreted signaling lipid modified glycoproteins.

2017年9月18日 · Here we used CRISPR/Cas9 somatic mutagenesis to test a patterning role for WntA, a signaling ligand gene previously identified as a hotspot of shape-tuning alleles involved in wing mimicry. We show that WntA loss-of-function causes multiple modifications of pattern elements in seven nymphalid butterfly species.

2023年7月26日 · WntA is another Wnt ligand that has been linked to the development and identity of cells involved in distinct color pattern elements including bands, patches, and eyespots in butterfly wings. Linkage mapping studies first identified WntA as an important prepatterning gene in Heliconius butterflies (38).

2018年7月25日 · To investigate these problems, we have analyzed the evolution of the Wnt ligand repertoire in the chordate phylum as a case study. We conduct an exhaustive survey of Wnt genes in genomic databases, identifying 156 Wnt genes in 13 non-vertebrate chordates.

2020年6月29日 · Among holometabolous insects, there are eight Wnt genes that are most commonly found: Wnt1, Wnt5, Wnt6, Wnt7, Wnt9, Wnt10, Wnt11, and WntA. Drosophila lacks only WntA; the functions of its seven Wnt genes include axis patterning in embryogenesis, control of the sexual dimorphic development of reproductive organs, development of neuroblast ...

2005年1月13日 · Here, we report the isolation of twelve Wnt genes from the sea anemone Nematostella vectensis 3, a species representing the basal group 4 within cnidarians. Cnidarians are diploblastic animals and...

En la edición en línea temprana de Proceedings of the National Academy of Sciences, revelan los sorprendentes resultados obtenidos al reescribir el gen WntA: en la naturaleza, un solo gen influye poderosamente en la exuberante diversidad de patrones de ala de mariposas.

Wnt genes encode evolutionary conserved secreted glycoproteins that act as signaling molecules essential for a number of fundamental processes in development and disease. The wg gene, the Drosophila counterpart of vertebrate Wnt-1, was first identified as a hypomorphic mutation leading to wing deficient flies.

在三只具有保守翼型排列的蝴蝶中，WntA是诱导条纹状模式（称为对称系统）所必需的，并获得了Vanessa前爪特有的新型眼点活化剂作用。 在两个Heliconius物种中，WntA指定黑色素场及其轮廓的浅色图案之间的边界。

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