2022年3月16日 · GARP是一种I型跨膜细胞表面对接蛋白，用于潜伏性转化生长因子-β1（TGF-β1）在活化的调节性T淋巴细胞、活化的B细胞和血小板上的表达。 GARP调节TGF-β1的定位和激活。 TGF-β1是一种多效性细胞因子，在细胞增殖、发育、凋亡、纤维化、血管生成、伤口愈合和癌症等生物学过程的许多方面发挥重要作用。 GARP已被确定为TGF-β1表达和激活的关键调节因子。 通过与Latent TGF-β1结合，GARP充当对接受体，将Latent TGF-β集中在细胞表面并增 …

hlx-60是一款garp单抗，可阻断tgf-β1的释放，从而减小tgf-β1的免疫抑制作用；同时，还可以引发adcc效应，清除garp+ treg。 2022年8月26日，HLX-60与PD-1单抗联用于实体瘤患者的I期临床试验于澳大利亚获批[4]。

2020年9月11日 · In human melanoma samples infiltrated by T cells and GARP-expressing Tregs, we found evidence of TGF-β signaling within the T cell compartment, suggesting that blockade of Treg-derived TGF-β1...

Glycoprotein-A repetitions predominant protein (GARP) associates with latent transforming growth factor-β (proTGFβ) on the surface of T regulatory cells and platelets; however, whether GARP functions in latent TGFβ activation and the structural basis of coassociation remain unknown.

Two anti-GARP monoclonal antibodies were generated that block the production of active TGF-β1 by human T regs. These antibodies recognize a conformational epitope that requires amino acids GARP 137–139 within GARP/TGF-β1 complexes. A variety of antibodies recognizing other GARP epitopes did not block active TGF-β1 production by T regs.

Two anti-GARP monoclonal antibodies recognize a conformational epitope within GARP-mTGF-β complex and block the production of active TGF-β from human Tregs. The two antibodies can effectively inhibit the immunosuppressive activity of human Tregs in a model of xenogeneic graft- versus - host disease in NSG mouse [ 103 ].

Regulatory T cells (T regs) suppress immune cells within close proximity by activating latent TGF-β1 presented by GARP (glycoprotein A repetitions predominant) to integrin αVβ8 on their surface. We solved the crystal structure of GARP:latent TGF-β1 bound to an antibody that stabilizes the complex and blocks release of active TGF-β1.

2018年2月20日 · GARP (glycoprotein-A repetitions predominant) is a type I transmembrane cell surface docking receptor for latent transforming growth factor-β (TGF-β) that is abundantly expressed on regulatory T lymphocytes and platelets. GARP regulates the availability of membrane-bound latent TGF-β and modulates its activation.

More recently, the protein GARP was shown to be involved in TGF-β1 activation by regulatory T cells (Treg), a subset of CD4 + T lymphocytes specialized in suppression of immune responses. GARP is a transmembrane protein that binds latent-TGF-β1 and tethers it on the Treg surface.

2012年1月25日 · Glycoprotein-A repetitions predominant protein (GARP) associates with latent transforming growth factor-β (proTGFβ) on the surface of T regulatory cells and platelets; however, whether GARP functions in latent TGFβ activation and the structural basis of coassociation remain unknown.