2025年3月30日 · GANC (Glucosidase Alpha, Neutral C) is a Protein Coding gene. Diseases associated with GANC include Pompe Disease and Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2A. Among its related pathways is Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy.

胸苷激酶蛋白（tk）可使无毒的丙氧鸟苷（ganc，也称为鸟嘌呤）转变为毒性核苷酸，而杀死细胞，因而可用丙氧鸟苷筛选排除随机整合的细胞株。 故同源重组时，G418和 GANC都有抗性，随机整合时对G418有抗性，但对GANC敏感，细胞将被杀死，无整合的将被G418杀死。

Neutral alpha-glucosidase C is an enzyme that in humans is encoded by the GANC gene. [5] [6] [7]

2020年2月5日 · The human GANC protein is coded by the ganc gene positioned on chromosome 15 (Martiniuk et al., 1980, Martiniuk et al., 1985, Hirschhorn et al., 2002). It was reported that in vitro it is able to release glucose from glycogen, as well as from low molecular-weight substrates, containing α-1,4-glycosidic linkages, under neutral pH ( Swallow et ...

2020年2月5日 · The fifth protein is called GANC. It is an α-glucosidase, which is able to release the terminal glucose from maltotriose and glycogen at neutral pH. Its subcellular localization and its physiological function have not been reported in scientific literature yet.

第五个蛋白称为ganc。它是一种α-葡萄糖苷酶，能够在中性ph下从麦芽三糖和糖原释放末端葡萄糖。其亚细胞定位及其生理功能尚未在科学文献中报道。我们的系统发育分析表明，ganc是从ganab的α亚基在早期脊椎动物中进化而来的。

关于 ganc Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:42,273,201-42,353,666 (from NCBI) This gene has 13 transcripts (splice variants), 207 orthologues and 6 paralogues.

2024年9月18日 · GANC glucosidase alpha, neutral C Gene ID: 2595, updated on 18-Sep-2024 Gene type: protein coding. Go to complete Gene record for GANC; Go to Variation Viewer for GANC variants; Summary. Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety.

2002年12月13日 · Hirschhorn et al. (2002) mapped the GANC gene to chromosome 15q15.1-q15.2 based on sequence similarity with a mapped STS. The mapped CAPN3 gene resides approximately 6 kb 3-prime of GANC.

in silico and physical cloning of two alleles of human neutral alpha-glucosidase (designated GANC on the human gene map) Reports the mapping of a 2-Mb interval on human chromosome 15q15 that contains 15 genes linked to congenital dyserythropoietic anemia type 1 (CDAI).