Galectin-9, through its regulation of AMPK, a kinase that negatively regulates mTOR, cooperates with Galectin-8-based effects to inactivate mTOR downstream of the lysosomal damaging agents and conditions.

在激活抗肿瘤特异性反应期间，外源性galectin-9调节抗原呈递，促进浆细胞样树突状细胞的分化，树突状细胞成熟和Th1极化微环境。此外，galectin-9在T细胞激活时被招募到免疫突触，促进近端TCR信号。这些结果表明galectin-9对T细胞的激活和扩张具有积极的调节作用。

2023年1月16日 · Galectin-9 knockout mice exhibit reduced IgA production following oral antigen exposure, which correlated with a reduced number of T helper 17 cells (T H 17 cells) and lower levels of IL-17 ...

2021年2月5日 · Here we show that PD-1 contributes to the persistence of PD-1 + TIM-3 + T cells by binding to the TIM-3 ligand galectin-9 (Gal-9) and attenuates Gal-9/TIM-3-induced cell death. Anti-Gal-9...

研究发现， PD-1通过与TIM-3配体Galectin-9(Gal-9)结合，有助于PD-1+TIM-3+T细胞的持续存在，并减弱了Gal-9/TIM-3诱导的细胞死亡。 Gal-9抗体 治疗可同时扩增瘤内TIM-3+细胞毒性CD8T细胞和免疫抑制调节性T细胞(Treg cell)，这限制了其效果。

2023年11月1日 · Galectin-9 (LGALS9), a member of the galectin family, is a widely expressed protein involved in immune regulation and tumor pathogenesis, and affects the prognosis of various types of cancer. Galectin-9 regulates immune homeostasis and tumor cell survival through its interaction with its receptor Tim-3.

2021年2月5日 · Gal-9 expression and secretion are promoted by interferon β and γ, and high Gal-9 expression correlates with poor prognosis in multiple human cancers. Our work uncovers a function for PD-1 in exhausted T cell survival and suggests Gal-9 as a promising target for immunotherapy.

Galectin-9 (LGALS9), a member of the galectin family, is a widely expressed protein involved in immune regulation and tumor pathogenesis, and affects the prognosis of various types of cancer. Galectin-9 regulates immune homeostasis and tumor …

Galectin-9 /LGALS9 蛋白是一种嗜酸性粒细胞趋化剂，可引导嗜酸性粒细胞（炎症反应中的关键免疫细胞）的迁移。 它还充当血管生成抑制剂，调节血管形成。 Galectin-9 /LGALS9 Protein, Mouse (GST) 是重组的 Galectin-9 /LGALS9 蛋白，由 E. coli 表达，带有 N-GST 标签。 Galectin-9 /LGALS9 蛋白充当嗜酸性粒细胞趋化剂，招募和迁移嗜酸性粒细胞，这是炎症反应中的关键免疫细胞。 它还充当血管生成抑制剂，调节血管形成并影响血管过程。 Galectin-9 /LGALS9 作为调 …

Galectin-9 (Gal-9) is a β-galactoside binding lectin known for its immunomodulatory role in various microbial infections. Gal-9 is expressed in all organ systems and localized in the nucleus, cell surface, cytoplasm and the extracellular matrix. It mediates host-pathogen interactions and …