Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N -acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding.

2023年1月16日 · The galectin family consists of carbohydrate (glycan) binding proteins that are expressed by a wide variety of cells and bind to galactose-containing glycans. Galectins can be located in the...

2023年3月16日 · 最近的研究表明肿瘤Galectin-3是一个有效的抑制性检查点，可抑制前列腺癌微环境中的淋巴细胞增殖。 此外，当树突状细胞疫苗用于前列腺癌时，galectin-3下调是淋巴细胞最佳激活的先决条件。 galectin -3调节T细胞和抗原呈递细胞之间的相互作用。 首先，galectin -3缺陷的未成熟树突状细胞具有缺陷的运动特性。 因此，通过控制树突状细胞从外周组织（包括肿瘤）向引流淋巴结的迁移，galectin -3在诱导抗肿瘤免疫反应中具有直接作用。 此外，这种特殊的半乳 …

Galectins are a family of carbohydrate-binding proteins with an affinity for beta-galactosides. Galectin-1 (Gal-1) is differentially expressed by various normal and pathological tissues and appears to be functionally polyvalent, with a wide range of …

Galectin：半乳糖凝集素。 半乳糖凝集素进化保守，具有结合聚糖的能力。 所有的半乳糖凝集素都含有一个或多个碳水化合物识别域（CRDs），负责与碳水化合物结合。

Galectins have many biological functions, including roles in development, regulation of immune cell activities, and microbial recognition as part of the innate immune system. This chapter describes the diversity of the galectin family and presents an overview of what is known about their biosynthesis, secretion, and biological roles.

Galectins are β -galcotosid-binding lectins. The function of galectins varies with their tissue-specific and subcellular location, and their binding to carbohydrates makes them key players in several intra- and extracellular processes where they bind to glycosylated proteins and lipids.

2022年5月9日 · Galectins are β-galactoside-binding animal lectins that contain one or two conserved carbohydrate recognition domains (CRDs) consisting of approximately 130 amino acids.

2018年5月1日 · Galectins are carbohydrate-binding proteins that are involved in many physiological functions, such as inflammation, immune responses, cell migration, autophagy and signalling. They are also linked to diseases such as fibrosis, cancer and heart disease. How such a small family of only 15 members can have such widespread effects remains a conundrum.

2023年12月1日 · Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in diverse biological processes including tissue repair, adipogenesis, immune cell homeostasis, angiogenesis, and pathogen recognition.