2025年3月30日 · GABRA6 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha6) is a Protein Coding gene. Diseases associated with GABRA6 include Ovarian Cancer and Epilepsy. Among its related pathways are Transmission across Chemical Synapses and GABA B …

Gamma-aminobutyric acid receptor subunit alpha-6 is a protein that in humans is encoded by the GABRA6 gene. [5] [6] GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels.

snRNA-seq结果显示,TBI+PTSD组小鼠前额皮质区Gabra6神经元数量明显增加。抑制皮层Gabra6可以减轻PTSD相关的行为结果。机制上, Smad3/4复合物 激活导致皮质神经元中Gabra6表达上调。

GABRA6 mutation, R46W, was identified as a susceptibility gene that may contribute to the pathogenesis of childhood absence epilepsy and cause neuronal disinhibition and increase in seizures via a reduction of alphabetagamma and alphabetadelta receptor function and expression

GABA 是哺乳动物大脑中的主要抑制性神经递质，它作用于 GABA-A 受体，即配体门控氯离子通道。 这些通道的氯离子电导可以通过与 GABA-A 受体结合的药物 (例如苯二氮卓类药物) 进行调节。 至少已鉴定出 16 个不同的 GABA-A 受体亚基。 [RefSeq 提供，2008 年 7 月] GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels.

2025年1月4日 · We tested the hypothesis that homocysteine (Hcy) antagonizes the GABA (A) receptor and behaves as an excitotoxic neurotransmitter that causes blood brain barrier (BBB) permeability and vascular dementia. Title: GABAA receptor agonist mitigates homocysteine-induced cerebrovascular remodeling in knockout mice.

2007年2月20日 · Alpha-6/GABRA6 subunits are found at both synaptic and extrasynaptic sites (PubMed:8632757). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity).

2024年12月16日 · 抑制皮层Gabra6可以减轻PTSD相关的行为结果。 机制上,Smad3/4复合物激活导致皮质神经元中Gabra6表达上调。 Gabra6与Homer1的相互作用激活了下游cAMP信号通路。

GABRA6, the gene that codes for GABRα6 subunit, is located at 5q31.1–q35 (Hicks et al., 1994) and is another member of the extrasynaptic GABAA receptors (Wafford, 2014). From: Schizophrenia Research, 2015

伽马氨基丁酸（GABA）是哺乳动物大脑中的主要抑制性神经递质，它在伽马氨基丁酸A受体上发挥作用，这些受体是配体门控的氯离子通道。 这些通道的氯离子传导可以被结合到伽马氨基丁酸A受体的药物如苯二氮卓类调节。 已经识别出至少16种不同的伽马氨基丁酸A受体亚型。 [RefSeq，2008年7月提供] Dir./Indir. ... Complete sequencing and characterization of 21,243 full-length human cDNAs. The status, quality, and expansion of the NIH full-length cDNA project: …