Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene. [5][6] GABA is the major inhibitory …

2025年3月30日 · GABRA5 (Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha5) is a Protein Coding gene. Diseases associated with GABRA5 include Developmental And Epileptic …

Restricted expression toward brain (RPKM 10.5). GABA 是哺乳动物大脑中的主要抑制性神经递质，它作用于 GABA-A 受体，即配体门控氯离子通道。 这些通道的氯离子电导可以通过与 …

study identified GABRA5 as a causative gene for early onset epileptic encephalopathy and expands the mutant GABRA1 phenotypic spectrum, supporting growing evidence that defects …

The GABRα5 gene (GABRA5) is localized to 15q11.2–q13 (Knoll et al., 1992) and is considered one of the extrasynaptic GABA A receptors involved in tonic inhibitory neurotransmission …

2023年8月31日 · GABRA5 LHA are a distinct subpopulation of GABAergic neurons and show decreased pacemaker firing in diet-induced obesity mouse models in males. Chemogenetic …

2025年2月8日 · Gabra5 receptors play a key role in the modulation of sweetened alcohol cue-induced reinstatement. Gabra5 overexpression increased tonic GABA currents and normalized …

2025年2月8日 · Enables GABA-A receptor activity and GABA-gated chloride ion channel activity. Involved in cochlea development; inner ear receptor cell development; and innervation. Acts …

2019年8月29日 · Gamma-aminobutyric acid (GABA) receptors are a family of proteins involved in the GABAergic neurotransmission of the mammalian central nervous system. GABRA5 is a …

In this study, we describe three individuals with epilepsy and developmental delay who were found to carry heterozygous missense variants in GABRA5, GABRA2, and GABRB3, and …