GABA Receptor - StatPearls - NCBI Bookshelf
2023年2月13日 · GABA receptors are receptors that respond when GABA is released into the post-synaptic nerve terminal. They are considered the chief inhibitory receptors for the central nervous system. GABA receptors are subdivided into GABAa and GABAb.
GABA receptor - Wikipedia
The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. There are two classes of GABA receptors: GABA A and GABA B.
GABAA receptor - Wikipedia
The GABA A receptor (GABA A R) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system.
GABAA receptors: structure, function, pharmacology, and related ...
γ-Aminobutyric acid sub-type A receptors (GABA A Rs) are the most prominent inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion channel with significant physiological and therapeutic implications.
GABAA receptors: structure, function, pharmacology, and …
2021年8月21日 · The mature receptor has a central chloride ion channel gated by GABA neurotransmitter and modulated by a variety of different drugs. Changes in GABA synthesis or release may have a significant effect on normal brain function. Furthermore, The molecular interactions and pharmacological effects caused by drugs are extremely complex.
Physiology, GABA - StatPearls - NCBI Bookshelf
2023年7月24日 · The GABA-A receptor is an ionotropic receptor that increases chloride ion conductance into the cell in the presence of GABA. The extracellular concentration of chloride is normally much higher than the intracellular concentration.
Structure, Function, and Modulation of GABAA Receptors - PMC
In the following, we attempt to give a brief overview of our knowledge of the biochemistry of GABA A receptors, including structure, function, and modulation. A more detailed review encompassing all Cys loop receptors has been published recently ( 9 ).
GABAA receptors: structure, function, pharmacology, and related ...
2021年8月21日 · γ-Aminobutyric acid sub-type A receptors (GABA A Rs) are the most prominent inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion channel with significant physiological and therapeutic implications.
GABA Receptor Physiology and Pharmacology - Basic …
Neurosteroids, which may be physiological modulators of brain activity, enhance GABA A receptor function. This enhancement by steroids involves direct action on the membrane receptor protein rather than through the classical genomic mechanism mediated by soluble high-affinity cytoplasmic steroid hormone receptors (see Chap. 49).
GABAA Receptors: Subtypes Provide Diversity of Function and ...
The differential sensitivity of GABA A receptor subtypes to anesthetics led to the identification of residues in the trans-membrane region of α and β subunits that are critical for modulation of GABA A-R function by volatile anesthetics like isoflurane, and high dose (≥100 mM) ethanol (Mihic et al., 1997).