Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. [5] [6] In mice, the enzyme is encoded by the Gsk3b gene. [7] Abnormal regulation and expression of GSK-3 beta is associated with an …

进一步机制研究发现，二甲双胍/低血糖组合的协同抗肿瘤作用由PP2A下游的糖原合成酶激酶3β（GSK3β）活化介导，导致肿瘤细胞中促存活蛋白MCL-1的表达降低和细胞死亡。 PP2A-GSK3β轴的特异性激活是二甲双胍诱导的CIP2A抑制的总和，PP2A抑制因子和PP2A调节亚基B56δ通过低葡萄糖上调，导致PP2A-B56δ复合物具有高亲和力的活性。 该研究的结果表明，PP2A-GSK3β-MCL-1通路的发现可能成为治疗肿瘤的靶点，但二甲双胍/低糖联合治疗在患者 …

2024年12月25日 · GSK3B (Glycogen Synthase Kinase 3 Beta) is a Protein Coding gene. Diseases associated with GSK3B include Cardiomyopathy, Familial Hypertrophic, 1 and Hematologic Cancer. Among its related pathways are Signaling by GSK3beta mutants and IL-9 Signaling Pathways.

GSK-3β2是大脑中表达的GSK-3β的选择性剪接变体。 GSK-3β已经与各种配体结晶。 它的总体形状为所有激酶所共有，包括一个主要由β折叠组成的小的N末端叶和一个主要由α螺旋组成的大的C末端叶。 ATP结合袋位于两叶之间。 Arg96、Arg180和Lys205形成一个小口袋，引物底物和假底物的磷酸基团在此结合。 GSK-3α/β受Ser21/9 (抑制性)和Tyr279/216 (激活性)磷酸化的调节。 GSK-3的磷酸-ser 21/9n-末端结构域作为假底物阻断底物接近催化位点。 含有未磷酸化 …

2021年11月27日 · Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively phosphorylate each substrate, and why was it evolutionarily favorable for GSK3 to assume such a large responsibility?

它是葡萄糖稳态的负调节剂，参与能量代谢、炎症、内质网应激、线粒体功能障碍和细胞凋亡途径。 该基因的缺陷与帕金森病和阿尔茨海默病有关。 [RefSeq 提供，2017 年 8 月] The protein encoded by this gene is a serine-threonine kinase belonging to the …

2017年8月17日 · Glycogen synthase kinase 3β (GSK3β) is a multifunctional protein kinase that targets Ser/Thr residues with a priming phosphorylation at the fourth amino acid on the...

GSK-3β is essential for the control of glucose metabolism, signal transduction, and tissue homeostasis. As more than 100 known proteins have been identified as GSK-3β substrates, it is sometimes referred to as a moonlighting kinase. Previous studies have elucidated the regulation modes of GSK-3β.

Glycogen Synthase Kinase 3 (GSK3) is one of the Serine/Threonine protein kinases, which has gained a lot of attention for its role in a variety of pathways. It has two isoforms, GSK3α and GSK3β. However, GSK3β is highly expressed in different areas of the brain and has been implicated in Alzheimer's disease as it is involved in tau phosphorylation.

糖原合成酶激酶-3 (GSK-3)是一种存在于所有真核细胞质中的丝氨酸/苏氨酸蛋白激酶,分为α和β两种亚型。 研究显示GSK-3β在调控糖代谢,细胞炎症反应,神经及心脏功能和生殖功能中具有重 …