Glutathione in the Brain - PMC - PubMed Central (PMC)
Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the antioxidant defense system and the maintenance of redox homeostasis in neurons. GSH depletion in the brain is a common finding in patients with ...
Imaging glutathione depletion in the rat brain using ascorbate …
2018年5月21日 · In this study, we applied these imaging probes to the normal rat brain and a rat model of glutathione depletion. We first studied hyperpolarized [1- 13 C]dehydroascorbate in the normal rat...
Glutathione in Brain Disorders and Aging - PMC - PubMed …
In rats, brain GSH levels that are already high in prenatal animals increase by approximately 20% during the first year of postnatal life and decline thereafter . GSH associates with molecules and signaling pathways that regulate iron metabolism, apoptosis, and thiol-redox control.
Glutathione in Brain: Overview of Its Conformations, Functions ...
Glutathione (GSH) is an important antioxidant found abundantly and synthesized intracellularly in the cytosol in a tightly regulated fashion. It has diverse physiological functions, including protection against reactive oxygen species and nitrogen species, antioxidant defense as well as maintenance of cellular thiol status.
Determination of extracellular glutathione in rat brain by ...
1994年11月18日 · A method for the continuous monitoring of extracellular glutathione (GSH) concentrations in rat brain has been developed. This method involved the in vivo sampling of brain extracellular fluid by microdialysis perfusion and the subsequent analysis by high-performance liquid chromatography (HPLC) with fluorescence detection.
In Vivo Brain GSH: MRS Methods and Clinical Applications - MDPI
2021年9月1日 · Glutathione (GSH) is an important antioxidant implicated in several physiological functions, including the oxidation−reduction reaction balance and brain antioxidant defense against endogenous and exogenous toxic agents. Altered brain GSH levels may reflect inflammatory processes associated with several neurologic disorders.
Glutathione in the Brain - PubMed
2021年5月9日 · Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the antioxidant defense system and the maintenance of redox homeostasis in neurons. GSH depletion in the brain is a common finding in patients with neurodegenerative diseases, such as Alzheimer's disease and Parkins …
Accurate measurement of reduced glutathione in gamma ...
2011年1月19日 · An accurate assay for the measurement of GSH in rat brain microvessels was developed, taking into account the high GGT activity expressed in this tissue compartment. Based on a sensitive fluorescence-based microtiter plate method using 2,3-naphthalenedicarboxyaldehyde as GSH-selective fluorogenic probe, …
Determination of extracellular glutathione in rat brain by
1994年11月18日 · A method for the continuous monitoring of extracellular glutathione (GSH) concentrations in rat brain has been developed. This method involved the in vivo sampling of brain extracellular fluid by microdialysis perfusion and the subsequent analysis by high-performance liquid chromatography (HPLC) wit …
Mechanism of Protein Carbonylation in Glutathione-Depleted Rat Brain ...
2017年12月20日 · The present study was designed to fill in some gaps in our knowledge on the mechanism of carbonylation upon acute GSH depletion. Utilizing DEM-treated rat brain slices, we herein demonstrate that protein carbonylation occurs mostly in mitochondria and to a lesser degree in organelles that also contain high levels of polyunsaturated lipids by ...