2025年3月26日 · Glioblastoma (GBM) is the most lethal primary brain tumor with intra-tumoral hierarchy of glioblastoma stem cells (GSCs). ... After isolating tumor cells in scRNA-seq datasets, we defined GSC-like ...

2021年3月24日 · The idea that GBM resistance could be dependent on innate differences in the sensitivity of clonogenic glial stem cells (GSCs) to chemotherapeutic drugs/radiation prompted the scientific community to rethink the understanding of GBM growth and therapies directed at eliminating these cells or modulating their stemness.

4 天之前 · SHP1705 is the first circadian clock-modulating compound to be found safe and well-tolerated in Phase I clinical trials. SHP1705 has increased selectivity for the CRY2 isoform and potency against GSC viability compared to previously published CRY activators, making it promising for applications in GBM where CRY2 levels are found to be low. SHP1705 prolonged survival in mice bearing GBM tumors ...

2024年3月20日 · 胶质母细胞瘤（ glioblastoma, GBM ）是恶性 程度最高的 原发性脑肿瘤， 患者 中位生存期低于 15 个月。 GBM 肿瘤细胞 具有高度异质性，而 其中 胶质母细胞瘤干细胞（ gl ioblastoma stem cell, GSC ）具有自我更新、细胞分化及肿瘤起始能力， 控制 肿瘤 的 生长和治疗 …

2021年2月22日 · Glioblastoma (GBM) is the most lethal primary brain tumor characterized by significant cellular heterogeneity, namely tumor cells, including GBM stem-like cells (GSCs) and differentiated GBM cells (DGCs), and non-tumor cells such as endothelial cells, vascular pericytes, macrophages, and other types of immune cells.

多形性胶质母细胞瘤 (glioblastoma multiforme, GBM) 是成人最常见和最具侵袭性的原发性脑癌。 即使采用了最佳的治疗方法(包括手术、放疗和化疗)，GBM患者的预后仍然很差。

2025年2月26日 · Another study induced GSC differentiation through stereotactical injection of a WNT inhibitor, an SHH inhibitor, and BMP . While effective, the intracranial application route could be clinically challenging and is likely to miss GBM cells, dispersed into the normal parenchyma that are not in reach of the injections.

2024年1月22日 · 胶质瘤干细胞（GSC）位于肿瘤细胞分化层级的顶端，在胶质母细胞瘤GBM的发生、发展和治疗抵抗中发挥关键作用。 蛋白翻译后加工，包括蛋白构象变化和蛋白翻译后修饰，可能在肿瘤细胞的干性获得和维持中扮演重要角色。 蛋白构象变化，特别是由肽基脯氨酸顺反异构酶（PPIases）催化的蛋白异构化，在肿瘤细胞生命活动的多个方面发挥关键调节作用。 Pin1是在肿瘤中研究最多的PPIase，在多种肿瘤中上调表达，已被发现超过100个底物靶蛋白，被公认为 …

1 天前 · Glioblastoma (GBM) is the most aggressive and lethal primary brain cancer. Despite standard therapies, surgical resection with radio- and chemotherapy, the 5-year survival rate remains a dismal 3 ...

2024年11月9日 · 胶质母细胞瘤（Glioblastoma Multiforme, GBM）是原发性脑肿瘤中最常见且致死率最高的恶性肿瘤。 尽管以免疫检查点抑制剂 为代表的的免疫疗法在诸多实体瘤中都展现出了巨大的治疗潜力， 但其对胶质母细胞瘤的疗效却并不理想 。