2019年2月12日 · Glucose regulatory protein 78 (GRP78), the master regulator of the UPR, plays a role in proliferation, invasion, and metastasis in cancer. Cancer stem cells (CSCs)...

2023年11月11日 · 条件培养基中 GRP78 的存在可改善随后的 ER 应激和内皮炎症，这在动脉粥样硬化形成中发挥着关键作用。 进一步的研究对于阐明释放机制和对靶细胞的影响非常重要。

GRP78/BiP is a major endoplasmic reticulum (ER) chaperone protein critical for protein quality control of the ER, as well as controlling the activation of the ER-transmembrane signaling …

To gain survival advantage, cancer cells exploit the adaptive aspects of the unfolded protein response such as upregulation of the ER luminal chaperone GRP78. The finding that when …

GRP78 is the master of the unfolded protein response (UBR) in the Endoplasmic Reticulum (ER) in normal cells. GRP78 force the unfolded proteins to refold or degrade using cellular …

Endoplasmic reticulum (ER) stress-mediated relocalization of ER chaperones to other cellular compartments allows cells to expand their functionality beyond the ER. Our finding that the ER …

The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum (ER)-resident molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins …

2022年11月14日 · As an essential ER chaperone and master regulator of the UPR, GRP78 is upregulated during ER stress and generally accepted as a canonical marker of ER stress …

2019年6月1日 · GRP78 is the master of the unfolded protein response (UBR) in the Endoplasmic Reticulum (ER) in normal cells. GRP78 force the unfolded proteins to refold or degrade using …

2008年6月13日 · We discovered that the UPR regulator and ER chaperone GRP78/BiP is required for stress-induced autophagy. In cells in which GRP78 expression was knocked down …