ER stress sensor, glucose regulatory protein 78 (GRP78 ... - Nature
2019年2月12日 · Glucose regulatory protein 78 (GRP78), the master regulator of the UPR, plays a role in proliferation, invasion, and metastasis in cancer. Cancer stem cells (CSCs)...
The stress-inducible ER chaperone GRP78/BiP is upregulated
2022年11月14日 · The molecular chaperone GRP78/BiP or HSPA5 that in humans is encoded by the HSPA5 gene, and has recently been identified as a host auxiliary factor for SARS-CoV-2 …
Glucose-regulated protein 78 modulates cell growth, epithelial ...
2022年1月24日 · Glucose-regulated protein 78 (GRP78) is a member of the heat shock protein 70 superfamily, which serves as an important regulator in many diseases. This study aims at...
Cell surface GRP78: An emerging imaging marker and therapeutic …
2020年12月10日 · In this review, we discuss the biological processes, functional importance and translocation mechanisms of cell surface GRP78 (csGRP78) in tumor cells. As a cancer …
Glucose-regulated protein (GRP78) is an important cell surface ... - PubMed
The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum (ER)-resident molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins …
Role of the Unfolded Protein Response Regulator GRP78/BiP in ...
GRP78 regulates ER stress–signaling pathways leading to UPR survival and apoptosis responses. In nonstressed cells, the ER-transmembrane signaling molecules (ATF6, IRE1, …
GRP78 is a novel receptor initiating a vascular barrier protective ...
2014年7月1日 · The present study examines a role of surface-expressed GRP78 as an initiator of the OxPAPC-mediated barrier-enhancing signaling cascade in vitro and in vivo. Our data …
GRP78 BiP (HSPA5)靶点介绍及实验小贴士| Abcam中文官网
GRP78 BiP靶点介绍 蛋白功能 可能在促进内质网上的多聚蛋白复合物的组装中起作用。 通过与DNAJC10的相互作用，参与蛋白质的正确折叠，同时，可能是为了促进DNAJC10从底物中释 …
<br>细胞表面 GRP78：新兴的成像标记物和癌症治疗靶点,Journal …
GRP78 在癌细胞和血管生成内皮细胞的表面过度表达，这使其成为不同类型的肽和抗体的有希望的靶标，可用于靶向癌症治疗或成像。 在这篇综述中，我们讨论了肿瘤细胞中细胞表面 …
GRP78-CAR T cells pro-duced high levels of Th1/Tc1 cytokines, with U87 cells eliciting the most robust response, followed by MDA-468 cells (Figures 2D, 2E, and S8).