GPX4---细胞铁死亡研究的“明星分子” - 知乎专栏
gpx4，又称磷脂过氧化氢谷胱甘肽过氧化物酶(phgpx)，是含硒gpx家族的第四位成员。 GPX4分子量约为19kDa，约由170个氨基酸组成。 目前已在哺乳动物中发现GPX1-GPX8等多个GPX家 …
Glutathione peroxidase 4 - Wikipedia
Glutathione peroxidase 4, also known as GPX4, is an enzyme that in humans is encoded by the GPX4 gene. [5] GPX4 is a phospholipid hydroperoxidase that protects cells against membrane …
谷胱甘肽过氧化酶4 (Glutathione Peroxidase 4 ，GPX4) - 知乎
2023年3月21日 · 谷胱甘肽过氧化物酶4(GPx4)是一种细胞内硒蛋白抗氧化酶，铁死亡重要的调节因子，具有清除膜脂过氧化氢产物、预防氧化应激的能力。 谷胱甘肽过氧化物酶4被认为是铁 …
GPX4 in cell death, autophagy, and disease - PMC - PubMed …
In this review, we first describe the structure and function of GPX4, then outline the novel roles of GPX4 in cell death and autophagy, and finally discuss the impact of GPX4 on embryonic …
GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
2023年5月1日 · Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …
Glutathione Peroxidase 4 (GPX4) - Abcam中文官网
Glutathione Peroxidase 4（GPX4）靶点介绍助您了解其功能和定位。同时列举了实用的WB实验小贴士，助您实验成功。
Palmitoylation-dependent regulation of GPX4 suppresses …
2025年1月20日 · Here, we elucidate that GPX4, an essential regulator of ferroptosis, is reversibly palmitoylated on cysteine 66. The acyltransferase ZDHHC20 palmitoylates GPX4 and …
gpx4表现出3种特性：一是该酶具有广泛的底 物，即使是在高度结构化脂质蛋白组装体中，如生 物膜和脂蛋白中，gpx4也能够减少复杂的脂质过 氧化物；二是gpx4不仅可以将还原型谷胱甘肽 …
GPX4: The hub of lipid oxidation, ferroptosis, disease and
Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of ferroptosis, …
GPX4, ferroptosis, and diseases - ScienceDirect
2024年5月1日 · GPX4 (Glutathione peroxidase 4) serves as a crucial intracellular regulatory factor, participating in various physiological processes and playing a significant role in …
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