GPR17 is a G protein coupled receptor that acts primarily through G proteins linked to the Gi alpha subunit but also to Gq alpha subunit. [7][11] Matching these structural relationships, GPR17 has been reported to be activated by cysteinyl leukotrienes (i.e. LTC4 and LTD4) as well as the purines (i.e., uridine, Uridine diphosphate (UDP), UDP-glu...

GPR17 receptors are considered to be sensors of local damage to the myelin sheath, and play a role in the reconstruction and repair of demyelinating plaques caused by ongoing inflammatory processes. GPR17 receptors are present on nerve cells and precursor oligodendrocyte cells.

该研究成果已于2020年10月26日以 Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia 为题发表于 Neuron。 由于OPCs参与成人的髓鞘形成，因此作者首先评估了OPCs在小鼠损伤（同侧）和对照（对侧）视神经中的增殖情况，发现损伤视神经中OPCs的数量在挤压损伤（crush injury）1-2周内显著增加并在4周后回到基线水平，而对照视神经OPCs的数量一直维持在低水平（图1A-C）。 进一步研究发现，损伤所诱导 …

2016年12月6日 · The GPR17 receptor is a G protein-coupled receptor (GPCR) that seems to respond to two unrelated families of endogenous ligands: nucleotide sugars (UDP, UDP-galactose, and UDP-glucose) and cysteinyl leukotrienes (LTD 4, LTC 4, and LTE 4), with significant affinity at micromolar and nanomolar concentrations, respectively. …

2018年3月14日 · Here, we demonstrate that the absence of Gpr17 enhances remyelination in vivo with a toxin-induced model whereby focal demyelinated lesions are generated in spinal cord white matter of adult mice...

2020年3月8日 · GPR17 receptors are considered to be sensors of local damage to the myelin sheath, and play a role in the reconstruction and repair of demyelinating plaques caused by ongoing inflammatory processes. GPR17 receptors are present on nerve cells and precursor oligodendrocyte cells.

2008年6月4日 · GPR17 is a G-protein-coupled receptor located at intermediate phylogenetic position between two distinct receptor families: the P2Y and CysLT receptors for extracellular nucleotides and cysteinyl-LTs, respectively.

2025年3月30日 · GPR17 (G Protein-Coupled Receptor 17) is a Protein Coding gene. Diseases associated with GPR17 include Periventricular Leukomalacia and Encephalomalacia. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

2021年6月12日 · Data mining with human LGG and GBM samples reveals that GPR17 is negatively correlated with glioma development. Overexpressing GPR17 inhibits glioma cell proliferation and induces apoptosis by...

GPR17是受半胱氨酰白三烯CysLTs及尿嘧啶核苷酸UDP双重调节的G蛋白偶联受体。 有报道表明GPR17是脑缺血损伤的一个损伤感受器。 脑缺血后的神经功能损伤，可由缺血直接引起也可由缺血后炎症所致的继发损伤引起。