GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine. [5] GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen.

2023年10月25日 · Glucose transporter 5 (GLUT5) is a membrane transporter that specifically transports fructose and plays a key role in dietary fructose uptake and metabolism. In recent years, a high fructose diet has occupied an important position in the daily intake of human beings, resulting in a significant incre …

葡萄糖转运体GLUT是一类负责机体葡萄糖进出入组织器官的关键门控蛋白，专职负责组织器官的能量供给和机体葡萄糖水平稳态调节功能。 某些特定GLUT的膜转运或功能受损是机体葡萄糖水平紊乱、高血糖和糖尿病产生的重要原因。 其中葡萄糖转运蛋白GLUT4是脂肪细胞和骨骼肌细胞内最主要的葡萄糖转运蛋白，胰岛素调控的GLUT4膜转运对于机体血糖平衡的维持至关重要。 因此GLUT4的转运障碍是机体产生 胰岛素抵抗 或患有 2型糖尿病 的主要表现之一。 在基础状态 …

2019年6月26日 · GLUT5 (SLC2A5) is a high-affinity fructose transporter primarily expressed at the apical surface of intestinal epithelial cells but also at lower levels in testis,...

2015年9月30日 · GLUT5 has a major facilitator superfamily fold like other homologous monosaccharide transporters. On the basis of a comparison of the inward-facing structures of GLUT5 and human GLUT1, a...

Fructose is transported passively across membranes by a member of the facilitative glucose transporter (GLUT) family, named GLUT5 (19, 20, 72, 98, 137). The GLUT family consists of 14 members divided into three major classes based on sequence homology and substrate selectivity, as described in recent reviews (97, 149).

果糖转运蛋白 GLUT5（促进扩散葡萄糖转运蛋白家族的同种型）的活性改变与 2 型糖尿病和肥胖症等疾病有关。 GLUT5 在某些肿瘤细胞中也过表达，抑制剂是这些疾病的潜在药物。

2021年3月24日 · We show that GLUT5 is a robust and generalizable driver of fructose-dependent cell proliferation. This indicates that fructose uptake is the limiting factor for fructose-mediated cell proliferation. We further demonstrate that cellular proliferation …

GLUT5 is a fructose transporter found in the apical membrane of enterocytes. GLUT6 is present in brain, spleen, and leukocytes and may be a glucose transporter.

Glucose transporter 5 (GLUT5) is a membrane transporter that specifically transports fructose and plays a key role in dietary fructose uptake and metabolism. In recent years, a high fructose diet has occupied an important position in the daily ...