Growth hormone secretagogue receptor (GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the "hunger hormone". [5][6] The role of GHS-R is thought to be in regulating energy homeostasis and …

The growth hormone (GH) secretagogue receptor (GHS-R1a) is a G protein-coupled receptor (GPCR) expressed in the brain as well as other areas of the body. In the early 1990s, this receptor was expression cloned in MERCK laboratories by using a group of synthesized small molecules known to increase GH …

该评论提供了有关模型动物大脑中生长素释放肽受体 GHS-R1a 表达的数据 ( Danio rerio、啮齿动物、灵长类动物）和人脑。研究表明 GHS-R1a 在大脑中广泛定位，这表明受体参与了许多生理过程。

GHS-R1a activation by its endogenous ligand ghrelin leads to the dissociation of α and βγ subunits of heterotrimeric G-proteins. The βγ dimer recruits G-protein-receptor kinases (such as GRK 2 or GRK 3) to the receptor, where they phosphorylate the agonist-bound receptor.

2020年12月1日 · Growth hormone secretagogue receptor 1a (GHSR1a), a member of the G protein-coupled receptor (GPCR) family, is a functional receptor of ghrelin. The expression levels and activities of GHSR1a are affected by various factors.

GHS-R1a is a G-protein-coupled receptor that, upon the binding of ghrelin or synthetic peptidyl and non-peptidyl ghrelin-mimetic agents known as GHS, preferentially couples to G q, ultimately leading to increased intracellular calcium content.

Ghrelin and the growth hormone secretagogue receptor 1a (GHS-R1a) are important targets for disorders related to energy balance and metabolic regulation. Pharmacological control of ghrelin signaling is a promising avenue to address health issues ...

最近研究发现，在黑质da能神经元中，生长激素促分泌素受体1a（ghs-r1a）能够与多巴胺2型受体（d2r）形成ghs-r1a/d2r异源二聚体，并且该异源二聚体的激活对pd黑质da能神经元具有重要意义。

2020年12月1日 · In its specific acylated form, Ghrelin activates the growth hormone secretagogue receptor-1a (GHS-R1a), a G protein coupled receptor (GPCR) identified as the first Ghrelin receptor, although other unidentified GHS-Rs likely exist [1].

生长激素促泌素受体1a（growth hormone secretagogue receptor，GHS-R1a）是营养素感应性胃肠肽ghrelin的公认受体，在下丘脑及下丘脑以外、与记忆和情绪调控密切相关的脑区（海马、皮层和杏仁核等）均有较丰富的表达，提示这些脑区的GHS-R1a参与调控学习记忆、焦虑及 ...