2006年2月1日 · High-affinity GHBP has been found in the circulation of many species and carries approximately one-half of circulating GH in humans. The role of GHBP in GH action appears …

2016年10月12日 · GH receptor (GHR) antagonist therapy is more effective but requires frequent high-dose injections. We have developed an alternative technology for generating a long …

GHR is a 638 amino acid long homodimeric receptor with one cytokine receptor homology domain (CRH), a single-pass transmembrane domain, and cytoplasmic intracellular domain (ICD) …

Both GH and GnRH have demonstrated potent neurotrophic, neuroprotective, and neuroregenerative action. Positive behavioral and cognitive effects are also associated with …

Here, we present the first data on the structure and function of a new set of protein antagonists with the full range of hGH actions—dual antagonists of hGH binding to the GHR as well as that …

2018年2月1日 · GHR signaling in humans with mutated GHR and absent GH counter-regulation is associated to less DNA damage and mutagenic events, efficient apoptosis, enhanced insulin …

2021年7月10日 · Growth hormone (GH) is critical for achieving normal structural growth. In addition, GH plays an important role in regulating metabolic function. GH acts through its GH …

Thirty-six distinct mutations of the receptor in the extracellular and transmembrane domains cause a clinical picture of severe GH/IGF-I deficiency, whereas two dominant negative mutations of …

The growth hormone receptor (GHR) mediates the effect of growth hormone (GH) on linear growth and metabolism. In humans, it exists as two isoforms differing by the retention or …

GHR也用于较低阶元的 分类，在 鼠总科 [13][14] 、 八齿鼠科 [15] 、 田鼠亚科 [16] 、 鼠亚科 [17] 、 白足鼠属 [18] 等啮齿动物，及 熊型总科 [19] 、 猫科 [20] 等 肉食动物 以及 皮翼目 [21] 的 …