上期我们特邀 北京大学医学院的赵艾博士对神经节苷脂的独特糖脂结构、人体分布以及来源进行揭秘，了解到乳类中神经节苷脂含量丰富，具备多样的功能，因此又被称为乳源性神经节苷脂（Gangliosides Milk Origin，gsM…

Gaucher disease type 1 (GD1) is a recessive genetic disease that affects 1 in 900 individuals in a particular population. GD1 is caused by a mutation in the enzyme glucocerebrosidase. Assuming the population is in Hardy-Weinberg equilibrium, calculate the frequency of the wild-type (nonmutant) allele for the enzyme glucocerebrosidase.

Gangliosides (GA) are glycosphingolipids containing sialic acid, existing in various sources, such as dairy products, eggs, brains and other tissues. The monosialoganglioside GM3 is the major GA species in mature human milk, while the disialoganglioside GD3 is the most abundant species in bovine milk and human colostrum.

2015年12月1日 · GM1, GM2 (2–6%), GD1 and GD2 have also been reported as ganglioside species in whole milk (Laegreid et al., 1986, Iwamori et al., 2008, Keenan, 1974). Iwamori et al. (2008) reported the presence of GM1, GM2, GM3, GD3, GT3 and other unspecified species.

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2008年5月23日 · Gangliosides from 1 ml of pooled human milk exhibited the ability to attenuate the binding of cholera toxin (30 ng) to GM1 by 93%, and those from 500 μl of goat milk completely inhibited the binding of botulinum type A neurotoxin 1.5 μg to GT1b.

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Sialic acids are important recognition sites in protein- and lipid-linked glycans of higher organisms and of select bacteria and protozoa. They are also prominent in human milk oligosaccharides.