2025年3月30日 · G3BP1 (G3BP Stress Granule Assembly Factor 1) is a Protein Coding gene. Diseases associated with G3BP1 include Chikungunya and Glioma Susceptibility 1 . Among its related pathways are SARS-CoV-2 Infection and Infectious disease .

2018年12月3日 · G3BP1 enhanced DNA binding of cGAS by promoting the formation of large cGAS complexes. G3BP1 deficiency led to inefficient DNA binding by cGAS and inhibited cGAS-dependent interferon (IFN)...

2025年2月9日 · G3BP1 promotes human breast cancer cell proliferation through coordinating with GSK-3beta and stabilizing beta-catenin. G3BP1 binds to guanine quadruplexes in mRNAs to modulate their stabilities. G3BP1 inhibits Cul3 (SPOP) to amplify AR signaling and promote prostate cancer.

Ras-GTPase-activating protein (GAP)-binding protein 1 (G3BP1) is a multi-functional protein that is best known for its role in the assembly and dynamics of stress granules. Recent studies have highlighted that G3BP1 also has other functions related to RNA metabolism.

2020年4月16日 · The molecular basis for stress granule assembly is a network of protein-RNA interactions with G3BP1 as the central node and molecular switch that triggers phase separation of granule components in response to free cytosolic RNA concentrations.

2022年5月5日 · Ras-GTPase-activating protein binding protein 1 (G3BP1) is a multifunctional binding protein involved in a variety of biological functions, including cell proliferation, metastasis, apoptosis, differentiation and RNA metabolism.

2020年4月16日 · Here, we show that SGs assemble through liquid-liquid phase separation (LLPS) arising from interactions distributed unevenly across a core protein-RNA interaction network. The central node of this network is G3BP1, which functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations.

Under physiological conditions, G3BP1 adopts a compact state that is stabilized by intramolecular interactions between the RG-rich and the acidic regions that inhibit phase separation (PubMed:32302570, PubMed:32302571, PubMed:32302572).

2020年10月5日 · Here, we show that the rasGAP SH3-binding protein 1 (G3BP1) is required for the activation of the senescent-associated secretory phenotype (SASP). During senescence, G3BP1 achieves this effect...

2018年12月11日 · The stress-granule protein G3BP1 forms a high-molecular-weight protein complex with the sensor cGAS and enhances its detection of cytoplasmic DNA.