2020年4月17日 · Jude Children’s Research Hospital的 J. Paul Taylor 组，题目为 G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules。 杨培国 博士等人首次在全基因组范围内筛选出了调控SG形成的重要蛋白组分，系统的研究了参与SG形成的蛋白网络以及重要组分在其形成中的作用。 该研究发现 SG的形成起始于一个包括G3BP1蛋白在内的核心SG网络，该网络由蛋白-蛋白、蛋白-RNA、RNA-RNA相互作用交织而成。 当相互协同作 …

2020年4月16日 · Biophysical studies revealed details of how G3BP1 functions as a molecular switch that triggers RNA-dependent LLPS. Importantly, interplay between three distinct intrinsically disordered regions (IDRs) in G3BP1 regulates its intrinsic propensity for LLPS, and this is fine-tuned by phosphorylation within the IDRs.

2021年8月29日 · Ras-GTPase-activating protein (SH3 domain)-binding protein (G3BP) is an RNA binding protein. G3BP is a key component of stress granules (SGs) and can interact with many host proteins to regulate the expression of SGs. As an antiviral factor, G3BP can interact with viral proteins to regulate the assembly of SGs and thus exert antiviral effects.

2024年1月31日 · G3BP1 is an RNA binding protein that condenses untranslating messenger RNAs into stress granules (SGs). G3BP1 is inactivated by multiple viruses and is thought to antagonize viral replication by SG-enhanced antiviral signaling. Here, we show that neither G3BP1 nor SGs generally alter the activation of innate immune pathways.

2025年3月30日 · G3BP1 (G3BP Stress Granule Assembly Factor 1) is a Protein Coding gene. Diseases associated with G3BP1 include Chikungunya and Glioma Susceptibility 1. Among its related pathways are SARS-CoV-2 Infection and Infectious disease. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and mRNA binding.

2024年8月27日 · We investigated the phylogenetic evolution of G3BP orthologs from unicellular yeast to mammals and identified both conserved and divergent features. The modular domain organization of G3BP orthologs is generally conserved. However, invertebrate orthologs displayed reduced capacity for SG assembly in human cells compared to vertebrate orthologs.

Polyclonal Antibody for studying G3BP-1. Validated for IF, WB. Highly specific and rigorously validated in-house, G3BP1 Antibody (CST #17798) is ready to ship.

根据这项研究，目前已知 g3bp 将结节性硬化复合体 (tsc) 与溶酶体连接在一起，并通过分子组雷帕霉素靶蛋白复合体 1 (mtorc1) 来抑制信号转导。 这一发现的意义重大，因为 mTORC1 过度活化与典型特征为细胞过度生长、迁移和神经元兴奋性的疾病有关。

这种酶是异质核 RNA 结合蛋白的成员，也是 Ras 信号转导通路的一个组成部分。 它通过与其 SH3 结构域相关联而特异性结合 Ras-GTPase 激活蛋白。 已经描述了该基因的几种可变剪接的转录本变体，但尚未确定其中一些变体的全长性质。 [RefSeq 提供，2008 年 7 月] This gene encodes one of the DNA-unwinding Enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion.