2021年10月15日 · Factor XI (FXI) is the zymogen of a plasma protease, factor XIa (FXIa), that contributes to thrombin generation during blood coagulation by proteolytic activation of several …

FXI is an unusual dimeric protease, with structural features that distinguish it from vitamin K–dependent coagulation proteases. The recent availability of crystal structures for zymogen …

2024年4月11日 · Domain-specific FXI inhibitors. This figure distinguishes the domains of FXI by color: A1 (orange), A2 (pink), A3 (blue), A4 (green), and catalytic (purple). Use of domain …

The coagulation protease zymogen factor (F)XI is a disulfide bond-linked homodimer, a configuration that is necessary for protein secretion and function. The non-catalytic portion of …

2024年4月16日 · Xisomab binds to FXI and to the A2 domain thereby preventing FXI activation by FXIIa . The other functions of FXI are not impacted. Monoclonal antibodies exhibit a rapid …

2025年2月1日 · We identified the FXI binding domains in 2 patients with severe acquired FXI deficiency. The autoantibody in patient 1 targeted the FXI catalytic domain. The autoantibody …

Current research involves evaluating various FXI-directed strategies, and phase 2 studies have shown promising results in orthopedic surgery, atrial fibrillation, end-stage renal disease …

2006年5月14日 · Factor XI (FXI), a coagulation protein essential to normal hemostasis, circulates as a disulfide-linked dimer. Here we report the full-length FXI zymogen crystal structure, …

2018年1月1日 · Factor XI (FXI) is a homolog of the plasma contact factor prekallikrein. FXI can function as a contact protein or as coagulation protein. FXI also serves as a bridge between …

2010年11月11日 · Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to experimentally–induced thrombosis, suggesting fXIIa activation of fXI contributes to thrombus …