AMB-FUBINACA (also known as FUB-AMB and MMB-FUBINACA[3]) is an indazole -based synthetic cannabinoid that is a potent agonist for the cannabinoid receptors, with Ki values of 10.04 nM at CB 1 and 0.786 nM at CB 2 and EC 50 values of 0.5433 nM at CB 1 and 0.1278 nM at CB 2, [4] and has been sold online as a designer drug. [5][6][7][8] It was orig...

ADB-FUBINACA and AMB-FUBINACA are two synthetic indazole-derived cannabinoid receptor agonists, up to 140- and 85-fold more potent, respectively, than trans -∆ 9 -tetrahydrocannabinol (∆ 9 -THC), the main psychoactive compound of cannabis.

FUB-AMB is a synthetic cannabinoid recently encountered on the designer drug market and has been found laced on plant material and marketed under the guise of herbal incense products. The chemical structure for FUB-AMB1 is shown below. There …

This substance is included in Schedule II of the 1971 Convention on Psychotropic Substances.

AB-FUBINACA (AMB-FUBINACA [2]) is a psychoactive drug that acts as a potent agonist for the cannabinoid receptors, with K i values of 0.9 nM at CB 1 and 23.2 nM at CB 2 and EC 50 values of 1.8 nM at CB 1 and 3.2 nM at CB 2.

2017年1月19日 · The synthetic cannabinoid methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate (AMB-FUBINACA, also known as MMB-FUBINACA or FUB-AMB) was identified in AK-47 24 Karat Gold...

2020年3月30日 · The Drug Enforcement Administration (DEA) places methyl 2-(1- (4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate (other names: FUB-AMB, MMB-FUBINACA, AMB-FUBINACA), including its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is...

2015年11月13日 · FUB-AMB is an analogue of AB-FUBINACA, a potent synthetic cannabinoid first synthesized by Pfizer. AB-FUBINACA exhibits a strong affinity (Ki =0.9 nM) for the CB1 receptor 1. The primary amide moiety in the L-valinamide side chain in AB-FUBINACA is replaced with a methyl ester in FUB-AMB.

Chemistry: FUB-AMB is methyl (2S)-2-[[1-[(4-fluorophenyl)methyl]indazole-3-carbonyl]amino]-3-methylbutanoate. FUB-AMB is in the S-configuration and contains a chiral center at the C-2 carbon of the valinate sidechain; hence, a R-AMB-FUBINACA enantiomer is possible.

FUB-AMB is a synthetic cannabinoid receptor agonist that is administered by smoking plant material sprayed with the substance or inhaling vapour after heating. Its mode of action suggests the potential for dependence and the likelihood of abuse.