2024年2月15日 · Pulmonary fibrosis is a lung disease that occurs when lung tissue becomes damaged and scarred. This thickened, stiff tissue makes it harder for the lungs to work properly. Pulmonary fibrosis worsens over time. Some people can stay stable for a long time, but the condition gets worse faster in others.

Fibrosis, also known as fibrotic scarring, is the development of fibrous connective tissue in response to an injury. Fibrosis can be a normal connective tissue deposition or excessive tissue deposition caused by a disease.

纤维化 （英語： fibrosis）是指正常 器官 或 组织 因受到超出自身 修复能力 的损伤后，受损处转化为由 成纤维细胞 与含有 胶原蛋白 、 纤连蛋白 的 细胞外基质 构成的纤维化组织的过程 [1][2] 。 在器官受到较轻微损伤时，组织中的成纤维细胞会参与修复过程，分泌细胞外基质并促进伤口收缩。 之后，受损部位很快会被再生的正常组织替代。 但是，在器官或组织受到严重损伤之后，成纤维细胞会分泌过量的细胞外基质，加之机体自身的再生能力无法完全修复损伤，造成受损部位最终 …

2023年1月16日 · Learn more about types of fibrosis, their causes, and risk factors. What Is Fibrosis? The term "fibrosis" is used to describe tissue that has overgrown, hardened, and/or scarred as a result of chronic inflammatory processes. Unlike acute inflammation, chronic inflammation lasts for months.

Fibrosis is a condition that develops slowly but eventually leads to tissue degeneration, which has devastating consequences for heart, lung, liver, kidney, and skin disorders [1]. It occurs when there is an excessive buildup of fibrous connective tissue in the extracellular matrix (ECM) area of tissues that have been injured.

纤维化（fibrosis）是一个医学概念，纤维化可发生于多种器官，主要病理改变为器官组织内纤维结缔组织增多，实质细胞减少，持续进展可致器官结构破坏和功能减退，乃至衰竭，严重威胁人类健康和生命。

Here we discuss the transformative experimental strategies that are being leveraged to dissect the key cellular and molecular mechanisms that regulate fibrosis, and the translational approaches that are enabling the emergence of precision medicine-based therapies for …

纤维化是由肌成纤维细胞在慢性炎症反应中过度沉积细胞外基质（ECM）蛋白引起的疤痕和组织硬化。 多种有害刺激（包括毒素、传染性病原体、自身免疫反应和机械应激）能够诱导纤维化细胞反应。 纤维化会影响身体的所有组织，如果不加以控制，会导致器官衰竭和死亡。 目前对调节纤维化发生的关键信号转导通路的研究已经确定了潜在的治疗靶标，以阻止纤维化的进展并恢复细胞功能。 为了响应组织损伤，源自多种来源的肌成纤维细胞（包括常驻成纤维细胞、间充质细胞 …

Large white spots caused a strong focal fibrosis and atrophy of lobules, that disappeared completely in the centre. This reactive fibrosis is distinct from the essential reparative fibrosis …

Pulmonary fibrosis is a serious lung disease that causes lung scarring and shortness of breath. Treatments may slow down scarring and help you breathe. There is no cure.