Lymph node fibroblastic reticular cells in health and disease
2015年5月22日 · Fibroblastic reticular cells — which are immunologically specialized myofibroblasts of mesenchymal origin — create a network within lymph nodes that is essential for immunological health ...
Fibroblastic reticular cells generate protective intratumoral T cell ...
2024年11月19日 · Specialized fibroblastic reticular cells (FRCs) underpin interconnected T cell environments with dedicated microenvironmental niches for FRC-T cell interaction, which promotes antitumor immunity in both human lung cancer and experimental murine lung tumors.
Differentiation and activation of fibroblastic reticular cells
2021年5月27日 · Secondary lymphoid organs (SLO) are underpinned by fibroblastic reticular cells (FRC) that form dedicated microenvironmental niches to secure induction and regulation of innate and adaptive immunity. Distinct FRC subsets are strategically positioned in SLOs to provide niche factors and govern efficient immune cell interaction.
Fibroblastic reticular cells enhance T cell metabolism and ... - Nature
2019年10月21日 · Nature Immunology - Fibroblastic reticular cells (FRCs) are dynamic regulators of lymphoid tissue structure. Turley and colleagues show FRCs also support activated T cells by producing IL-6,...
Fibroblastic Reticular Cells: Organization and Regulation of the T ...
2015年2月2日 · In particular, FRCs are concentrated in the paracortical region (T cell zone) of the LN and are endowed with several functions that regulate the activity of T lymphocytes. FRCs are thought to originate from mesenchymal preadipocyte precursors in the microenvironment of the LN anlagen during ontogeny (7).
New fibroblast network connections support lymphocytic ... - Nature
2023年6月15日 · Single-cell RNA sequencing distinguishes subsets of fibroblastic reticular cells and predicts pathways that support immune function via crosstalk with lymphocytes.
Lymph node fibroblastic reticular cells steer immune responses - Cell …
2021年7月10日 · High-resolution genetic and phenotypic studies have recently unveiled discrete fibroblast reticular cell (FRC) subsets in mice and humans; these harbor distinct functions and microanatomic distributions. FRC clusters create a variety of …
Lymph node fibroblastic reticular cells steer immune responses
Lymph nodes (LNs), where immune responses are initiated, are organized into distinctive compartments by fibroblastic reticular cells (FRCs). FRCs imprint immune responses by supporting LN architecture, recruiting immune cells, coordinating immune cell crosstalk, and presenting antigens.
Human lymph node fibroblastic reticular cells maintain …
2024年7月19日 · Fibroblastic reticular cells (FRCs) are mesenchymal stromal cells in human lymph nodes (LNs) playing a pivotal role in adaptive immunity. Several FRC subsets have been identified, yet it remains to be elucidated if their heterogeneity is maintained upon culture.
Fibroblastic reticular cells at the nexus of innate and adaptive …
2019年4月11日 · Fibroblastic reticular cells (FRC) coordinate innate and adaptive immune responses in lymphoid organs. (A) FRC recognize pathogen-associated molecular patterns and integrate cellular signals from immune cells such as cytokines and growth factors.
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