ERK signalling: a master regulator of cell behaviour, life and fate
2020年6月23日 · ERK signalling in the neural crest is primarily driven by FGF and platelet-derived growth factor (PDGF) signalling, and its key effectors are SRF and its cofactors TCF and …
FGF/ERK signaling pathway: how it operates in mammalian
The combination of genetic and pharmacological tools allowing disruption of the fibroblast growth factor / extracellular signal-regulated kinase (FGF/ERK) pathway, together with animal models …
The role of FGF/Erk signaling in pluripotent cells
2010年10月15日 · Intriguing recent findings suggest an important role for FGF/extracellular signal-regulated kinase (Erk) signaling in promoting the transition from a naïve to a primed …
Frontiers | FGF Signaling Pathway: A Key Regulator of Stem Cell ...
2020年2月17日 · Maintaining stemness of mouse and human PSCs relies on distinct extrinsic signaling pathways including leukemia inhibitory factor (LIF)/signal transducer and activator of …
FGF stimulation of the Erk1/2 signalling cascade triggers
Here, we delineate the role of autocrine production of fibroblast growth factor 4 (Fgf4) and associated activation of the Erk1/2 (Mapk3/1) signalling cascade. Fgf4 is the major stimulus …
分子所汪阳明课题组发现控制FGF/ERK通路和胚胎干细胞自我更新 …
2019年3月26日 · 汪阳明研究团队决定寻找抑制FGF/ERK信号通路的长非编码RNA，把研究聚焦在一个既有酶活性又有RNA结合功能的蛋白TRIM71上。...
A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK …
2019年3月25日 · Here, the authors demonstrate that the lncRNA Trincr1 binds and represses TRIM71 in ES cells, leading to downregulation of SHCBP1 protein, the reduction of FGF/ERK …
Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate …
2020年11月9日 · Our results show primarily active ERK in both the inner cell mass and trophectoderm cells due to fibroblast growth factor (FGF) signaling. Strikingly, a subset of …
FGF 通路 | Thermo Fisher Scientific - CN
FGF 通过与 FGFR 结合并激活多个信号转导通路向细胞核发出信号，包括涉及 Ras 、 MAPK（丝裂原活化蛋白激酶）、 ERK（细胞外信号调节激酶）、 Src 、p38MAPK 、 PLC- γ（磷脂酶 …
Endogenous FGFs drive ERK-dependent cell fate patterning in 2D …
2024年11月8日 · We have shown that in a stem cell model for early human gastrulation, FGF-dependent ERK signaling is directly required for differentiation to PS-like cells and their …