2011年7月27日 · Introduction Several factors, including diuretic use and sepsis, interfere with the fractional excretion of sodium, which is used to distinguish transient from persistent acute kidney injury (AKI). These factors do not affect the fractional excretion of urea (FeUrea). However, there are conflicting data on the diagnostic accuracy of FeUrea. Methods We conducted an …

2013年10月13日 · A low FENa and FEUrea is highly prevalent in the first hours of sepsis. In sepsis, oliguria is an earlier sign of impending AKI than increase in serum creatinine. A combination of a high FENa and a low FEUrea is associated with intrinsic AKI, whereas a combined high FENa and FEUrea is strongly predictive of transient AKI.

2016年5月29日 · Background Oliguria is one of the leading triggers of fluid loading in patients in the intensive care unit (ICU). The purpose of this study was to assess the predictive value of urine Na+ (uNa+) and other routine urine biomarkers for cardiac fluid responsiveness in oliguric ICU patients. Methods We conducted a prospective multicenter observational study in five …

2013年3月26日 · In the group with transient AKI, FeUrea increased significantly from H0 to H24 (from29% (21 to 39%) to 42% (30 to 51%), P < 0.001) (Figure 2; Table S1 in Additional file 1). Nosignificant changes in FeUrea occurred in the group with persistent AKI (P =0.08). In none of the three groups did FeNa or the U/P creatinine ratio changesignificantly.

2011年7月27日 · Diagnostic performance of FeUrea Median FeUrea was 37% (26 to 49) overall, 39% (28 to 40) in patients without AKI, 41% (29 to 54) in patients with transient AKI and 32% (22 to 51) in patients with persistent AKI (P = 0.12). Figures 1a, b and 1c show the distributions of FeNa, FeUrea and urine/plasma (U/P) urea ratios, respectively, in each group.

2010年12月1日 · excretion of urea (FEUrea) <35%. There was a stepwise increase in prevalence of AKI based on urinary output, with quartiles of decreasing FENa and FEUrea at d0t0 (P =0.05andP = 0.01) and d0t4 (P < 0.001 for both), but not at d1 for FENa ( P = 0.18). No such asso-ciation was noted for AKI based on creatinine (Table 3).

(FeNa) and the fractional excretion of urea (FeUrea) are believed to be reliable for separating transient AKI from persistent AKI [4,5,7-9]. However, these indices may be affected by diuretic agents or sepsis [10]. In addition, little information is available on their performance for separat-ing transient AKI from persistent AKI in critically ill

2014年10月21日 · We review original research in the field of critical care nephrology accepted or published in 2013 in Critical Care and, when considered relevant or linked to these studies, in other journals. Three main topics have been identified and are discussed for a rapid overview: acute kidney injury (diagnosis, risk factors and outcome); timing and modality of renal …

RESEARCH Open Access Urine sodium concentration to predict fluid responsiveness in oliguric ICU patients: a ...

2013年4月15日 · Pre-renal AKI is classically differentiated from AKI of other etiologies by fractional excretion of sodium (FeNa) < 1% or fractional excretion of urea (FeUrea) < 35% [23–25]. However, FeNa can be confounded by diuretic use and is altered in the setting of sepsis, whereas FeUrea decreases with age, and a multicenter trial reported that it was ...