2025年3月30日 · FBXO32 (F-Box Protein 32) is a Protein Coding gene. Diseases associated with FBXO32 include Left Ventricular Noncompaction and Dilated Cardiomyopathy. Among its related pathways are Class I MHC mediated antigen processing and presentation and Gene expression (Transcription). An important paralog of this gene is FBXO25.

F-box only protein 32, also known as "MAFbx", for "Muscle Atrophy F-box gene", and "Atrogin-1," is a protein that in humans is encoded by the FBXO32 gene. [5][6][7] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box.

2024年5月27日 · F-框蛋白 32 （FBXO32），也被称为 MAFbx ，表示“ 肌肉萎缩 F-box 基因 ”， 是由 FBXO32 基因编码的蛋白质。该基因编码 F-box 蛋白家族的成员，其特 征 在 于 大 约 40 个 氨 基 酸 基 序 F-box 。

F-box 蛋白分为 3 类：包含 WD-40 结构域的 Fbws、包含富含亮氨酸重复序列的 Fbls 和包含不同蛋白质-蛋白质相互作用模块或无可识别基序的 Fbxs。 该基因编码的蛋白质属于 Fbxs 类，含有一个 F-box 结构域。 这种蛋白质在肌肉萎缩期间高度表达，而发现缺乏这种基因的小鼠对萎缩有抵抗力。 因此，该蛋白质是治疗肌肉萎缩症的潜在药物靶标。 可变剪接导致编码不同异构体的多个转录变体。 [RefSeq 提供，2011 年 6 月]

2025年2月8日 · Title: A novel likely pathogenic variant in the FBXO32 gene associated with dilated cardiomyopathy according to whole‑exome sequencing. Ubiquitin E3 ligase Atrogin-1 protein is regulated via the rapamycin-sensitive mTOR-S6K1 signaling pathway in …

2024年8月27日 · FBXO32，也称为肌肉萎缩F-box蛋白（MAFbx）或atrogin-1，早在二十多年前被鉴定为一种肌肉特异性E3连接酶。近期研究揭示了FBXO32在肿瘤发生中的多重作用。重要的是，FBXO32通过为乳腺癌中的上皮–间质转化进程创建适宜环境来促进转移。

2025年2月8日 · A novel likely pathogenic variant in the FBXO32 gene associated with dilated cardiomyopathy according to wholeexome sequencing. Ubiquitin E3 ligase Atrogin-1 protein is regulated via the rapamycin-sensitive mTOR-S6K1 signaling pathway in C2C12 muscle cells. FBXO32 targets PHPT1 for ubiquitination to regulate the growth of EGFR mutant lung cancer.

2024年4月20日 · Using a proteomic-based approach combined with computational analyses, we found a positive correlation between FBXO32 and the PI3K/AKT/mTOR pathway, and identified PTEN as a FBXO32 interactor....

2017年11月15日 · We show that FBXO32-dependent K63-linked ubiquitination of CtBP1 is required for its nuclear retention, which is essential for mediating transcriptional changes via epigenetic reprogramming of...

FBXO32-001: 6744: 355aa: ENSP00000428205.1 . Gene/transcipt that contains an open reading frame (ORF). Protein coding. CCDS6345: Q0VAQ6 Q498Y9 Q969P5: NM_148177.2: A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and ...