FBW7 (F-box and WD repeat domain-containing 7) is an F-box protein that binds to key regulators of cell division and growth, including cyclin E, MYC, JUN and Notch. Most FBW7 substrates are...

2023年3月18日 · FBXW7 is a main tumor suppressor due to its ability to control proteasome-mediated degradation of several oncoproteins such as c-Jun, c-Myc, Cyclin E1, mTOR, and Notch1-IC. FBXW7 inactivation in...

2020年11月3日 · Here, we report that in response to radiation, oxidative stress, or bleomycin, the E3 ubiquitin ligase FBW7 mediates cell senescence and tissue fibrosis through telomere uncapping. FBW7 binding to telomere protection protein 1 (TPP1) facilitates TPP1 multisite polyubiquitination and accelerates degradation, triggering telomere uncapping and DNA ...

FBW7 is a key substrate recognition subunit of the Skp1-Cul1-F-box-protein E3 ubiquitin ligase. FBW7 targets for ubiquitination and destruction of numerous crucial transcription factors and protooncogenes, including cyclin E, c-Myc, c-Jun, Notch and MCL-1.

2018年4月6日 · In this study, we examined the expression pattern of FBW7 and its prognostic valve in glioma specimens, tested the inhibitory effect of FBW7 overexpression on cell malignancies of glioblastoma with special regard to TMZ chemoresistance, and, finally, explored the underlying mechanisms of FBW7 regulation in cell cycle, apoptosis and the related ...

FBW7 is one of the most well characterized F-box proteins that serve as substrate recognition subunits of SCF (Skp1-Cullin 1-F-box proteins) E3 ubiquitin ligase complexes. SCFFBW7 plays key roles in regulating cell cycle progression, ...

4 天之前 · FBXW7是一种抑制肿瘤生长的SCF E3泛素连接酶。 在大多数情况下，FBXW7识别磷酸化底物并促进它的泛素化降解【1】。 目前报道，FBXW7主要通过泛素化降解几个关键促癌蛋白，包括c-Myc、MCL-1、c-Jun、Notch1和cyclin E而发挥抑癌功能。 SHOC2充当RAS和RAF的支架在秀丽隐杆线虫（c.elegans）中被首次报道，并激活RAS/ERK通路【2】。 在大多数癌症中，SHOC2的表达上调【3】。 在哺乳动物细胞中，mTOR存在于两种多蛋白复合物中：Mlst8 …

2020年1月14日，浙江大学医学院附属第一医院、转化医学研究院赵永超课题组在Cell Reports杂志发表题为“FBXW7 Confers Radiation Survival by Targeting p53 for Degradation”的研究论文，该研究揭示了泛素连接酶FBXW7通过泛素化降解p53来调控肿瘤细胞放疗敏感性的新机制。

2011年11月29日 · Fbw7 is a member of the F-box protein family which is characterized by the F-box motif, an approximately 40-amino acid region. Fbw7 serves as a substrate adaptor for the Skp1–Cul1–F-box protein–Rbx1 (SCF) ubiquitin ligase complex and mediates the recognition and binding of the substrate proteins.

2014年10月10日 · Fbw7 regulates stem cells, differentiation, and genome stability. Studies of normal tissues have provided valuable insights into pathways that are also important for tumorigenesis. Fbw7 loss profoundly affects differentiation and proliferation in stem and progenitor cell types, often through similar mechanisms.