凋亡相关因子配体(Factor-related Apoptosis ligand,FASL）
2023年3月21日 · FasL是能够结合到死亡受体TNFRSF6/FAS的细胞因子，在T-cell发育中介导其由于细胞毒性引起的凋亡。 FasL基因位于1号染色体，与OX-40L基因相邻，由5个外显子组成。
人人学懂免疫学：第二十五期|免疫学|CTL|穿孔素|颗粒酶|靶细胞|杀 …
2021年8月2日 · CTL杀伤的第二种方法是：利用其表面的一种称为Fas配体（FasL）的蛋白质，与靶细胞表面的Fas蛋白结合，从而诱发靶细胞内的“自杀程序”，使靶细胞因凋亡而死亡。
FAS-ligand regulates differential activation-induced cell death …
2015年5月7日 · In particular, Th1 cells express high level of FAS-ligand (FASL), which interacts with FAS and leads to caspases’ cleavage and ultimately to cell death. In contrast, low FASL …
Signaling and transcriptional control of Fas ligand gene expression ...
2003年3月25日 · Fas ligand (FasL), a member of the tumor necrosis factor family, initiates apoptosis by binding to its surface receptor Fas. As a consequence, there is sequential …
王建莉、蔡志坚课题组在Nature Communications发文揭示Fas调 …
北京时间2019年7月2日，浙江大学基础医学院免疫学研究所王建莉、蔡志坚课题组在在线发表题为“Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor …
Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune …
Differential signaling pathway by membrane-bound FasL (mFasL) and soluble FasL (sFasL). mFasL leads to the recruitment of FADD and activates caspase pathways. mFas promotes …
Fas Pathway | Thermo Fisher Scientific - TH
Explore the Fas signaling pathway and find antibodies to detect some of its target proteins, including FasL, Fas, c-FLIP, and caspase 8.
Fas-Fas Ligand: Checkpoint of T Cell Functions in Multiple
2016年9月27日 · Fas and Fas Ligand (FasL) are two molecules involved in the regulation of cell death. Their interaction leads to apoptosis of thymocytes that fail to rearrange correctly their T …
Apoptosis induced by FasL and TRAIL/Apo2L in the
2001年11月1日 · In Graves’ disease, FasL expression in thyroid follicular cells is induced by thionamides and kills infiltrating lymphocytes. In this condition, Th-2-type cytokines upregulate …
如何理解fas与fasL？ - 答魔科研
FasL表达在活化的T细胞、NK细胞及免疫豁免区的细胞，如睾丸Sertoli细胞、眼角膜上皮细胞等，另外在一些肿瘤细胞中也可以检测到的FasL的存在。 3。 Fas阳性表达的组织细胞与活化T …