Cytotoxic CD8 + T cells in cancer and cancer immunotherapy
2020年9月15日 · In addition, Fas ligand (FASL) is expressed on CD8 + T cells and its ligation by Fas receptors on target cells activates death domains (Fas-associated protein with death …
CD8+T细胞知识分享 - 知乎 - 知乎专栏
CD8+T细胞，也称为细胞毒性T细胞（Cytotoxic T Lymphocytes，CTLs），是免疫系统中的关键效应细胞，主要负责识别和摧毁被病毒感染的细胞以及癌变细胞。 CD8+T细胞源于骨髓中的造 …
The dual functions of Fas ligand in the regulation of peripheral CD8 ...
Although Fas ligand (FasL) is well characterized for its capacity to deliver a death signal through its receptor Fas, recent work demonstrates that FasL also can receive signals facilitating …
Fas/FasL Signaling Regulates CD8 Expression During Exposure to …
2021年3月24日 · Our data describes how Fas and FasL upregulation differs depending on the setting of CD8 T cell activation and demonstrates that Fas/FasL signaling maintains CD8 …
Fas/FasL signaling is critical for the survival of exhausted antigen ...
2019年3月1日 · To determine whether Fas/FasL signaling is critical for the induction of apoptosis in activated CD8 + T cells during the tumor immune response, we examined the fate of OVA …
Fas/FasL signaling is critical for the survival of exhausted antigen ...
We found that the number of generated Ag-specific activated CD8 + T cells decreased via apoptosis during a prolonged tumor immune response. However, the number of Ag-specific …
Expression of Fas/FasL in CD8+ T and CD3+ Foxp3+ Treg cells ... - PubMed
The expression of an apoptosis marker (annexin V) and the death receptor Fas in CD8+T cells and FasL in CD3+Foxp3+T cells were evaluated. Serum TGF-β1 levels in patients with HCC …
Fish requires FasL to facilitate CD8 - Oxford Academic
2025年3月10日 · Mechanistically, tilapia T cells utilize mTORC1/c-Myc axis to regulate pathogen-induced FasL expression, which binds to Fas and activates caspase-8/caspase-3 pathway, …
FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8 - Springer
2020年2月8日 · Our study highlighted that FasL directly modulated the cytotoxicity of CD8 + T cells to neurons in stroke and PDPK1 was identified as a key downstream molecule of FasL …
The many roles of FAS receptor signaling in the immune system
The role of FASL-FAS induced apoptosis in normal as well as pathological killing of target cells. Both classical CD8 + cytotoxic T cells as well as a portion of activated CD4 + T cells express …