Immune deficient Fah-knockout mice can be repopulated with human hepatocytes, creating "mice with human livers". These chimeric animals have become an important preclinical model for infectious diseases, metabolism and gene therapy.

2007年7月29日 · To provide a broadly useful hepatic xenorepopulation system, we generated severely immunodeficient, fumarylacetoacetate hydrolase (Fah)-deficient mice. After pretreatment with a...

2023年8月28日 · 为此，作者利用了公认的肝细胞人源化系统：MISTRG Fah-/-小鼠【3】，在MISTRG Fah-/-小鼠中植入人CD34+FLCs和人肝细胞（图2），成功实现了肝细胞和NPCs在同一小鼠宿主中的共人源化，人源化的小鼠肝组织包括了人免疫细胞、内皮细胞和星状细胞等。

2011年5月11日 · Notably, transplanted iHep cells repopulate the livers of fumarylacetoacetate-hydrolase-deficient (Fah−/−) mice and rescue almost half of recipients from death by restoring liver functions. Our...

018454 NOD.Cg- Rag1 tm1Mom Fah em1Mvw Il2rg tm1Wjl /MvwJ These FNRG mice contain a ZFN-mediated mutation that disrupts the Fah gene, and knock-out alleles of the Rag1 and Il2rg genes. This strain may be useful as a xenorecipient platform for human hepatocytes.

To provide a broadly useful hepatic xenorepopulation system, we generated severely immunodeficient, fumarylacetoacetate hydrolase (Fah)-deficient mice. After pretreatment with a urokinase-expressing adenovirus, these animals could be highly engrafted (up to 90%) with human hepatocytes from multiple sources, including liver biopsies.

敲除Fah基因exon 3，建立Fah基因敲除小鼠模型。 应用领域 ：酪胺酸血症第一型研究相关 *使用本品系发表的文献需注明: Fah-KO(M-NSG) mice (Cat. NO. NM-NSG-004) were purchased from Shanghai Model Organisms Center, Inc..

2014年3月30日 · To investigate the potential of CRISPR-Cas9–mediated in vivo genome editing in adult animals, we used a mouse model of hereditary tyrosinemia type I (HTI), a fatal genetic disease caused by...

NPG-Fah敲除小鼠，是维通达公司自主研发的一系列肝脏损伤免疫缺陷小鼠模型之一。 小鼠Fah基因位于7号染色体，采用CRISPR-Cas9技术在Fah基因1号外显子上编辑产生indel 引起移码突变，从而实现该基因在NPG小鼠上的敲除。

In the present study, we also found that Fah-/-mice withdrawal NTBC and transplanted with human hepatocytes (NTBC-OFF Fah-/-mice with HHT) gradually gained weight by six weeks after human hepatocyte transplantation, indicating recovery of liver function and high levels of liver regeneration in these mice .