For all 11 eyes with an eccentric PRL, the underlying retinal areas appeared to have normal FAF. In addition, the visual field sensitivities associated with the PRLs were within ±2 dB of the mean sensitivity values for each of the 11 patients.

Microperimetry, fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT) were performed. The location and stability of the PRL along with the associated FAF pattern and visual sensitivities were determined and compared to the underlying retinal structure.

2024年10月9日 · Macular microperimetry has the dual purpose of quantifying retinal sensitivity and measuring the preferred retinal locus (PRL). It was performed under mesopic...

FAF and SD-OCT were obtained on 22 eyes of 11 patients with Stargardt disease. SD-OCT images were obtained at the fovea and at the eccentric preferred retinal locus (PRL). The diameters of “absent” (hypo-autofluorescent) and “abnormal” FAF areas were measured.

Purpose : Development of Preferred Retinal Loci (PRL) eccentric to the fovea is an adaptive mechanism that follows irreversible central vision loss due to macular atrophy from different pathologies. This prospective observational study describes the structural and functional characteristics of the PRL using high resolution imaging modalities.

The visual sensitivity of the surrounding retinal region was measured with static perimetry and the relationship of the PRL to fundus abnormalities examined by overlaying the perimetric and fixation results onto the fundus photograph and onto the fundus autofluorescence (FAF) images.

Purpose: To study longitudinal changes in preferred retinal location (PRL) and visual function in Stargardt disease (STGD) and assess their relationship to changes in short wavelength fundus autofluorescence (SW-FAF) and retinal structure measured with spectral domain optical coherence tomography (SD-OCT).

The location of PRLs in patients with macular disease and the relationship among areas of altered FAF, the PRL and visual sensitivity were investigated. Eccentric PRLs were in the superior retina in regions with normal FAF. Hypofluorescence was associated with markedly decreased sensitivity, but hyperfluorescence corresponding to flecks was not.

2024年12月21日 · 眼底自发荧光（FAF）是一种无创成像技术，可通过采集LF在RPE细胞内的分布状态，客观反映ARMD的病情变化。 本文涵盖了FAF原理的介绍、ARMD中FAF成像的回顾，以及ARMD研究中FAF对地图状萎缩（GA）和早期ARMD表型的最新分类，并总结了ARMD发病过程中萎缩进展和脉络膜新生血管形成的关系。 眼底自发荧光原理. 自发荧光（AF）是指某些分子在被合适的波长光激发时发光的现象。 这些激发分子被称为荧光团，可分为外源性和内源性。 前 …

FAF and SD-OCT were performed on 22 eyes of 11 patients with Stargardt disease. SD-OCT images were obtained at the fovea and at the eccentric preferred retinal locus (PRL). The diameters of absent (hypoautofluorescence) and abnormal FAF areas were measured.