Factor H (FH) is a member of the regulators of complement activation family and is a complement control protein. It is a large (155 kilodaltons), soluble glycoprotein that circulates in human plasma (at typical concentrations of 200–300 micrograms per milliliter [5][6][7]).

因子H （FH）是流体相和表面AP的主要调节因子。 它有可能通过识别碳水化合物来区分宿主细胞表面和病原体. 如含唾液酸的糖胺聚糖，它们是特异性的存在于宿主细胞表面，它会迅速抑制C3b的任何意外沉积，防止进一步的补体激活以及对宿主组织的损伤。 人体因子H（FH）由七种高度相关的蛋白质组成，FH，因子H-1和因子H- 5（FHRs;FHR-1-5）相关蛋白。 FH/FHR1- 5编码基因的常见和罕见变异与多种疾病（包括癌症、感染性疾病、自身免疫性疾病、肾脏疾病、眼部疾病和 …

Complement factor H is a soluble complement regulator essential for controlling the alternative pathway in blood and on cell surfaces. Normal recognition of self cell markers (i.e. polyanions) and C3b/C3d fragments is necessary for factor H function.

Factor H is a major soluble regulator of the alternative complement pathway, but it can also bind to host cells and tissues, protecting them from complement attack. Interactions of factor H with various endogenous ligands, such as pentraxins, extracellular matrix proteins and DNA are important in limiting local complement-mediated inflammation.

2012年2月7日 · Factor H is a major soluble regulator of the alternative complement pathway, but it can also bind to host cells and tissues, protecting them from complement attack. Interactions of factor H with various endogenous ligands, such as pentraxins, extracellular matrix proteins and DNA are important in limiting local complement-mediated inflammation.

Factor H is a 150 kDa single chain plasma glycoprotein that plays a pivotal role in the regulation of the alternative pathway of complement. Primary sequence analysis reveals a structural organization of this plasma protein, in 20 homologous units, called Short Consensus Repeats (SCRs), each about 60 amino acids long.

2009年6月7日 · Factor H (FH) is an abundant regulator of complement activation and protects host cells from self-attack by complement. Here we provide insight into the regulatory activity of FH by solving the...

2020年12月15日 · Factor H (FH), a member of the regulators-of-complement-activation (RCA) family of proteins, circulates in human plasma at concentrations of 180-420 mg/L where it controls the alternative pathway (AP) of complement in the fluid phase and on cell surfaces.

Complement factor H (fH) is purified from normal human serum. It is an essential regulatory component of the alternative pathway of complement. It is critical for prevention of complement activation on host cells and tissues, especially the kidney.

Complement factor H/CFH Protein, Human (431a.a, HEK 293, His) 是一种带有 His 标签的重组补体因子H (CFH) 蛋白。 人补体因子 H 是补体中央控制蛋白，是补体激活调节因子家族的成员。