FTY720是近几年新开发的一种 免疫抑制剂，该药选择性减少外周循环 淋巴细胞数，显著延长实验动物移植器官的生存，同时并不损害对病毒的免疫应答及免疫记忆功能，毒副作用低，并且与 CsA 、 FK506 、RAD等临床一线免疫抑制药物显示出良好的协同作用，在 肾移植 病人的一期临床试用效果良好，临床应用前景广阔。 经过多年的发展， 器官移植 已成为治疗各种终末期脏器功能衰竭的有效手段，尤其是 CsA 等 免疫抑制剂 的临床应用，在很大程度上解决了移植术后排斥反应 …

Fingolimod is a sphingosine-1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes, preventing them from contributing to an autoimmune reaction. It has been reported to reduce the rate of relapses in relapsing-remitting multiple sclerosis by approximately one-half over a two-year period. [5]

fty720 减弱小胶质细胞增生，通过减少 lps 介导的 p38 mapk 信号通路激活来调节小胶质细胞炎症表型。因此，fty720 具有直接的神经保护和抗炎特性，可促进整体神经保护。

fty720 进入体内后，迅速磷酸化成 fty720-p，fty720-p 能够诱导淋巴细胞表面的s1pr1持续内化并降解掉。因此，fty720 是一种s1pr1的激动剂，拮抗s1p与受体结合的生物学作用，导致 t、b 淋巴细胞滞留在淋巴器官内，减少其在血液、淋巴液和黏膜等的分布。

The chemical modification of ISP-I yielded a new compound, FTY720, which has more potent immunosuppressive activity and less toxicity than ISP-I does. FTY720 has been shown to be highly effective in experimental allotransplantation models and autoimmune disease models.

Oct 29, 2010 · Oral fingolimod (FTY720/Gilenya; Novartis) is a first-in-class sphingosine 1-phosphate (S1P) receptor modulator that, in relapsing–remitting MS, has demonstrated...

Fingolimod hydrochloride (Fingolimod HCl, FTY720, FTY-720)，又称盐酸芬戈莫德，是有效的1-磷酸鞘氨醇(S1P)的拮抗剂，IC 50 为0.33 nM，也是S1P受体的激动剂，在复发型多发性硬化症治疗中有重要作用。

Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC 50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant.

Fingolimod hydrochloride (FTY720) is a first-in-class of sphingosine-1-phosphate (S1P) receptor modulator approved to treat multiple sclerosis by its phosphorylated form (FTY720-P). Recently, a novel role of FTY720 as a potential anticancer drug has ...

Fingolimod (FTY720) is a specific agonist that targets the remaining barrier-protective S1P receptors, without targeting S1PR2. In the present study, we explored whether FTY720 treatment can alleviate DENV-induced endothelial hyperpermeability.