FIP200 (focal adhesion kinase family interacting protein of 200 kD) is a newly identified essential autophagy gene and a component of the ULK-Atg13-FIP200 complex. We show that mice lacking FIP200 in hematopoietic cells (CKO mice) experience perinatal lethality associated with severe erythroblastic anemia.

Atg1是第一个在酵母中被成功克隆的自噬基因,哺乳动物中的同源基因为ULK1 (unc-51-like kinase 1)。ULK1是自噬泡形成所必需的一种蛋白，以复合物的形式存在, 与至少三种蛋白质组成复合物：ATG13，FIP200和ATG101。

2008年5月5日 · We next screened for ULK binding proteins and identified the focal adhesion kinase family interacting protein of 200 kD (FIP200), which regulates diverse cellular functions such as cell size, proliferation, and migration. We found that FIP200 was redistributed from the cytoplasm to the isolation membrane under starvation conditions.

RB1CC1/FIP200 is an essential macroautophagy/autophagy protein that plays an important role in a variety of biological and disease processes through its canonical autophagy-dependent and -independent functions. However, it remains largely unknown whether post-translational modifications could regula …

We next screened for ULK binding proteins and identified the focal adhesion kinase family interacting protein of 200 kD (FIP200), which regulates diverse cellular functions such as cell size, proliferation, and migration. We found that FIP200 was redistributed from the cytoplasm to the isolation membrane under starvation conditions.

2022年10月4日 · Ca 2+ transients induce formation of fusion-prone, liquid-like FIP200 puncta. The mechanism that initiates autophagosome formation on the ER in multicellular organisms is elusive.

FIP200 (FAK-family Interacting Protein of 200 kDa) has emerged from recent studies as a critical signaling node to coordinately regulate cell growth, cell proliferation, cell survival and cell spreading/migration. There is also increasing evidence that dysregulation of FIP200 is linked to embryonic death and cancer development in adult life.

2021年3月10日 · Here, the authors show that interactions of ULK subunit FIP200 with autophagy receptors CCPG1 and Optineurin can be regulated by phosphorylation, suggesting a general binding mode shared by ...

2022年2月11日 · This work describes how the ULK1 complex assembles, the first structural characterization of FIP200 and how ULK1 scaffolds autophagy initiation through both direct interactions with NDP52 and interaction with membranes.

2021年7月29日 · Here we show that the FAK family kinase-interacting protein of 200 kDa (FIP200) facilitates RIG-I activation. FIP200 deficiency impaired RIG-I signaling and increased host susceptibility to RNA...