2025年3月30日 · FGR (FGR Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FGR include Hematologic Cancer and Placental Insufficiency. Among its related pathways are ADORA2B mediated anti-inflammatory cytokines production and Regulation of actin dynamics for phagocytic cup formation.

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively.

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal site s for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively.

编码的蛋白质包含用于豆蔻酰化和棕榈酰化的 N 末端位点、PTK 结构域以及 SH2 和 SH3 结构域，它们分别参与介导与含磷酸酪氨酸和富含脯氨酸的基序的蛋白质-蛋白质相互作用。 该蛋白质定位于质膜褶皱处，并作为由 beta-2 整合素信号转导通路触发的细胞迁移和粘附的负调节剂发挥作用。 感染 Epstein-Barr 病毒会导致该基因的过度表达。 已经鉴定出编码相同蛋白质的多个可变剪接变体。 [RefSeq 提供，2008 年 7 月] This gene is a member of the Src family of Protein …

2024年6月17日 · the Src tyrosine kinase Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR) is associated with suberoylanilide hydroxamic acid resistance. Title: A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma.

2025年2月8日 · Gene ID: 14191, updated on 8-Feb-2025. Enables several functions, including immunoglobulin receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity.

2024年3月5日 · This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively.

FGR is expressed in human and murine hematopoietic cells including granulocytes, monocytes/macrophages, natural killer cells, platelets, and erythrocytes (Berton 2006; Lowell 2004). Its function has been mainly characterized in innate immunity cells and in particular in granulocytes and monocyte/macrophages (Berton et al. 2005; Lowell 2004).

Tyrosine-protein kinase Fgr is a protein in humans that is encoded by FGR gene. Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in ...

Enables several functions, including immunoglobulin receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including defense response to Gram-positive bacterium; integrin-mediated signaling pathway; and regulation of vesicle-mediated transport.