Fibroblast growth factor 21 (FGF-21) is a protein that in mammals is encoded by the FGF21 gene. [5][6] The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family and specifically a member of the endocrine subfamily which includes FGF23 and FGF15/19.

FGF21 has been proposed as a novel therapeutic for metabolic complications such as diabetes and fatty liver disease. This review aims to interpret and delineate the ever-expanding complexity of FGF21 physiology.

2021年3月18日 · As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as an endocrine hormone that signals to distinct targets throughout the body.

2020年8月6日 · Fibroblast growth factor 21 (FGF21) is a stress-inducible hormone that has important roles in regulating energy balance and glucose and lipid homeostasis through a heterodimeric receptor...

2022年2月23日 · Fibroblast growth factor 21 (FGF21) is a fasting or stress inducible metabolic hormone produced mainly in the liver. It plays important roles in regulating both glucose and lipid homeostasis via interacting with a heterodimeric receptor complex comprising FGF receptor 1 (FGFR1) and β-klotho (KLB).

2025年3月30日 · FGF21 (Fibroblast Growth Factor 21) is a Protein Coding gene. Diseases associated with FGF21 include Combined Oxidative Phosphorylation Deficiency 8 and Hepatocellular Clear Cell Carcinoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as an endocrine hormone that signals to distinct targets throughout the body. Interest in therapeutic applications for FGF21 was initially sparked by its ability to …

2019年4月16日 · Fibroblast growth factor 21 (FGF21) is a hormone that regulates important metabolic pathways. FGF21 is expressed in several metabolically active organs and interacts with different tissues. The FGF21 function is complicated and well debated due to its different sites of production and actions.

2025年3月26日 · Gene target information for FGF21 - fibroblast growth factor 21 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

2017年4月4日 · Our data reveal that the acute and chronic effects of FGF21 can be dissociated through adipose-dependent and -independent mechanisms. The body possesses at least three distinct types of adipocytes: white, beige or brite, and brown adipocytes.