In immunology, an Fc receptor is a protein found on the surface of certain cells – including, among others, B lymphocytes, follicular dendritic cells, natural killer cells, macrophages, neutrophils, eosinophils, basophils, human platelets, and mast cells – that contribute to the protective functions of the immune system.

On innate immune effector cells, activating and inhibitory FcγRs set a threshold for cell activation by immune complexes. Important examples for effector responses that are regulated by FcγRs are...

2020年7月2日 · Fc-gamma receptors (FcγRs) recognize IgG-coated targets, such as opsonized pathogens or immune complexes (ICs). Cross-linking leads to internalization of the cargo with associated activation of down-stream signaling cascades.

The Fc gamma receptors (FcγRs) are a family of cell‐surface proteins that are expressed on a variety of lymphoid, myeloid, and non‐immune cells, which function by binding the Fc portion of immunoglobulin G (IgG).

The Fc-gamma receptors (FcγRs) are receptors for the Fc region of immunoglobulin (Ig)G, and are involved in a multitude of innate and adaptive immune responses, including mediating the specific recognition of antigens by leucocytes 1,2.

Fc gamma receptor is essential participant in many immune system effector functions, such as phagocytosis of opsonized, release of inflammatory mediators and antibody-dependent cellular cytotoxicity. There are three major classes of Fc gamma receptor receptors depending on the affinity of receptor.

2007年12月7日 · Immune complexes bind to activating Fc receptors (FcR) and inhibitory FcRs that are expressed by innate immune effector cells such as basophils, mast cells, neutrophils, monocytes and macrophages, in which they trigger the indicated effector responses.

The Fc gamma receptors (FcγR; subtypes FcγR1A, FcγRIIA and FcγRIIIA) of the immunoglobulin superfamily are the best characterized receptors for phagocytosis in macrophages and monocytes.

2021年11月10日 · Fc receptors (FcRs) are a group of glycoproteins that belong to the immunoglobulin superfamily and are classified, like Fc alpha receptors (FcαRs), Fc gamma receptors (FcγRs) and Fc epsilon...

Indeed, FcγRs (via IgG antibodies) confer neutrophils with a key feature of the adaptive immunity: an antigen-specific cell response. This review summarizes the expression and function of FcγRs on human neutrophils in health and disease and how …