Mono-ubiquination of FANCD2 is essential for repairing DNA interstrand crosslinks, and clamps the protein on DNA together with its partner protein FANCI. The monoubiquitinated FANCD2:FANCI complex coats DNA in a filament-like array, potentially as a way to protect DNA associated with stalled replication.

2025年3月30日 · FANCD2 (FA Complementation Group D2) is a Protein Coding gene. Diseases associated with FANCD2 include Fanconi Anemia, Complementation Group D2 and Fanconi Anemia, Complementation Group A. Among its related pathways are Gene expression (Transcription) and miRNA regulation of DNA damage response.

范可尼贫血是一种遗传异质性隐性疾病，其特征是细胞遗传学不稳定、对 DNA 交联剂过敏、染色体断裂增加和 DNA 修复缺陷。 Fanconi 贫血互补组的成员不具有序列相似性；它们通过组装成一个共同的核蛋白复合物而相关。 该基因编码互补组 D2 的蛋白质。 这种蛋白质被单泛素化以响应 DNA 损伤，导致其与参与同源定向 DNA 修复的其他蛋白质 (BRCA1 和 BRCA2) 定位于核灶。 可变剪接导致多个转录本变体。 [RefSeq 提供，2016 年 2 月]

2024年7月31日 · FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular mechanism that reconciles the roles of...

2024年1月23日 · While the Fanconi anemia pathway has a well-characterized function in DNA crosslink repair, its newly uncovered role in regulating R-loop metabolism has not been fully understood. Olazabal-Herrero et al. reveal that FANCD2 functions in NXF1-SRSF1-mediated mRNA export regulation, preventing R-loop formation and subsequent genomic instability.

FANCD2的单泛素化在时间和空间上受FA核心复合物（E3环连接酶）、USP1:UAF1（去泛素化酶）和ATR激酶的调控。 FANCI是FANCD2的 异源二聚体，在这一调控中起着重要作用。 特别是，FANCI本身是FA核心复合物的单泛素化靶点，又是ATR激酶的底物，并含有FANCD2去泛素化所必需的USP1:UAF1的结合位点。 在ICL修复过程中，FANCD2作为异源二聚体与FANCI结合，向含有泛素结合域的DNA修复蛋白发出信号，并通过 同源重组 或转译合成促进DNA修复。 摘要部 …

FANCD2 inhibits ferroptosis by regulating the JAK2/STAT3 pathway in osteosarcoma. FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells. Optimized structure of monoubiquitinated FANCD2 (human) at Lys …

2017年8月19日 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, especially in the cellular responses to DNA damage. Here, we discuss the recent and relevant studies to provide an updated review on the roles of FANCD2 in the DNA damage response.

FANCD2是FA基因家族中的一员，已成为FA信号传导的焦点。研究发现，FANCD2在肿瘤的发生发展中发挥重要作用并能够作为铁死亡(ferroptosis)的相关基因参与调节铁死亡。

2017年8月19日 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, especially in the cellular responses to DNA damage. Here, we discuss the recent and relevant studies to provide an updated review on the roles of FANCD2 in the DNA damage response.