FABP4 (亦称为 A- FABP 或 aP2)主要存在于脂肪组织和巨噬细胞中， 在调节代谢和炎症反应中发挥着重要作用。 物质简介. 脂肪酸结合蛋白家族是脂质结合蛋白超家族成员,广泛存在于哺乳动物的小肠、肝、心、脑、骨骼肌等多种细胞内。 到目前为止,已证实有9种不同的组织特异分布的脂肪酸结舍蛋白,它们分别是肝脏型、肠型、肌肉和心脏型、脂肪细胞型、表皮型、回肠型、脑型、髓鞘型和睾丸型。 脂肪酸结合蛋白是一族多源性的小分子胞内蛋白质,其主要作用是调节脂肪酸的摄 …

2025年3月30日 · FABP4 (Fatty Acid Binding Protein 4) is a Protein Coding gene. Diseases associated with FABP4 include Liposarcoma Of Bone and Familial Partial Lipodystrophy. Among its related pathways are Epigenetic regulation by WDR5-containing histone modifying complexes and PPAR signaling pathway.

Fatty acid-binding protein 4 (FABP4), also known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays an important role in the development of insulin resistance and atherosclerosis in relation to metaflammation.

2024年12月19日 · fabp4具有高度亲脂性,能够结合多种不同长度和饱和度的脂肪酸。它可以通过与游离脂肪酸结合形成脂肪酸-fabp4复合物,从而促进脂肪酸在细胞内的运输与储存。fabp4也参与了葡萄糖代谢、验证和血管病变等生理过程,在调控脂代谢和相关疾病中发挥重要作用。

2015年8月11日 · In particular, genetic deficiency and small molecule-mediated inhibition of FABP4 (also known as aP2) and FABP5 can potently improve glucose homeostasis and reduce atherosclerosis in mouse models.

3 天之前 · FABP4, known as A-FABP or aP2, is a key member of the FABP family. Recent studies have reported that exogenous FABP4 inhibits myocardial cell contraction. Increased plasma FABP4 levels are positively correlated with BMI and insulin resistance index, and are also associated with lipid metabolism disorders.

Fatty acid-binding protein 4 (FABP4), known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays important roles in the development of insulin resistance and atherosclerosis in relation to metabolically driven low-grade and chronic inflammation, referred to as ‘metaflammation’.

Objective: Fatty acid binding protein 4 (FABP4) is an intracellular lipid chaperone involved in the crosstalk between adipose and peripheral tissues, and it contributes to widespread insulin resistance in cells, including cardiac cells.

2025年3月26日 · FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008] Expression

3 天之前 · FABP4 plays a critical role in transporting fatty acids from the extracellular to the intracellular compartment. Mechanistically, obesity promotes excessive fatty acid uptake, leading to aberrant lipid accumulation and reduced ATP production in USMCs. These abnormalities stem from weakened coupling of mitochondria-associated membranes, which ...