基因序列中的一些名词区别（CDS、Exon、Intron、UTR、ORF、 …
外显子 （expressed region），是真核生物基因的一部分，它在剪接后仍会被保存下来，并可在蛋白质生物合成过程中被表达为蛋白质。 外显子是最后出现在成熟RNA中的基因序列，又称表 …
能否简单易懂的介绍外显子（exon），内含 …
断裂基因/中断基因 是指在DNA序列中，一系列可被表达成RNA或蛋白质的DNA片段（也就是外显子exon）被一系列不能转录成RNA或翻译成蛋白质的DNA片段（也就是intron）给分割开来。
The structure of pathogenic huntingtin exon 1 defines the bases …
2023年3月2日 · Integrative data analysis reveals that the poly-Q tract adopts long α-helical conformations propagated and stabilized by glutamine side chain to backbone hydrogen …
The pathogenic exon 1 HTT protein is produced by incomplete
2017年5月2日 · We found that the HTTexon1 mRNA is present in fibroblasts from juvenile HD patients and can also be readily detected in the sensory motor cortex, hippocampus and …
Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT …
2024年8月18日 · We have developed an engineered microRNA targeting the HTT exon 1 sequence (miHTT), delivered via adeno-associated virus serotype 5 (AAV5). The target …
Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT
2024年12月3日 · We have developed an engineered microRNA targeting the HTT exon 1 sequence (miHTT), delivered via adeno-associated virus serotype 5 (AAV5). The target …
Truncation of mutant huntingtin in knock-in mice demonstrates ... - Nature
2020年5月22日 · Here, using CRISPR/Cas9 to truncate full-length mutant HTT in HD140Q knock-in (KI) mice, we show that exon 1 HTT is stably present in the brain, regardless of truncation …
The structure of pathogenic huntingtin exon 1 defines the
2023年3月3日 · We show that α-helical stability is a stronger signature in defining aggregation kinetics and the structure of the resulting fibrils than the number of glutamines. Our …
Interaction between huntingtin exon 1 and HEAT repeat structure …
Huntington disease (HD) is associated with aggregation of huntingtin (HTT) protein containing over 35 continuous Q residues within the N‐terminal exon 1 encoded region. The C‐terminal of …
The pathogenic exon 1 HTT protein is produced by incomplete
2017年5月2日 · We have previously shown that exon 1 of the huntingtin gene does not always splice to exon 2 resulting in the production of a small polyadenylated mRNA (HTTexon1) that …