
v5 ABE-eVLP - Addgene
2024年11月13日 · Plasmid v5 ABE-eVLP from Dr. David Liu's lab contains the insert MMLVgag(C507V)–ABE8e and is published in Nat Biotechnol. 2024 Nov 13. doi: …
Directed evolution of engineered virus-like particles with improved ...
2024年11月13日 · Engineered virus-like particles (eVLPs) are promising vehicles for transient delivery of proteins and RNAs, including gene editing agents. We report a system for the …
Engineered virus-like particles for efficient in vivo delivery of ...
2022年1月11日 · Methods to deliver gene editing agents in vivo as ribonucleoproteins could offer safety advantages over nucleic acid delivery approaches. We report the development and …
Engineered virus-like particles for transient delivery of ... - Nature
2024年1月8日 · Here we report prime editor engineered virus-like particles (PE-eVLPs) that deliver prime editor proteins, prime editing guide RNAs and nicking single guide RNAs as …
Cell重磅:刘如谦开发新型类病毒载体,安全高效进行体内基因编 …
2022年1月12日 · 刘如谦团队开发了一种工程化类病毒颗粒(Engineered virus-like particles,eVLP),能够克服蛋白复合物递送的多个瓶颈: 1)eVLP是无DNA的,直接递送 …
NBT | 刘如谦团队开发定向进化的工程化类病毒颗粒,提升生产和 …
2024年11月15日 · 衣壳突变组合提高eVLP效能 通过对36种衣壳突变体的筛选和组合优化,作者发现GagC507V–ABE与GagQ226P–Pro–Pol组合(v5 BE-eVLPs)显著提高了eVLP的基因编辑 …
工程病毒样颗粒的定向进化,提高生产和转导效率-抗生素研究与再 …
2024年11月,Aditya Raguram等研究人员在Nature Biotechnology上发表了题为“Directed evolution of engineered virus-like particles with improved production and transduction efficiencies”的研 …
Directed evolution of engineered virus-like particles with
2024年11月13日 · Directed evolution of engineered virus-like particles with improved production and transduction efficiencies. Nat Biotechnol. 2024 Nov 13. doi: 10.1038/s41587-024-02467-x. …
‘带货’能力更强的递送载体eVLP定向进化——让基因编辑/蛋白质递 …
研究人员开发了一种针对工程病毒样颗粒 (eVLP)的定向进化系统,创建了具有增强的生产、转导和基因编辑效率的第五代eVLP,为改善基因传递载体在治疗中的应用铺平道路。 最近发表在 …
By engineering VLPs to overcome cargo packaging, release, and localization bottlenecks, we developed fourth-generation eVLPs that mediate efficient base editing in several primary …