Etomoxir ( (R)- (+)-Etomoxir，乙莫克舍) - 仅供科研 - MCE
Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in …
Etomoxir - Wikipedia
Etomoxir, or rac-Ethyl 2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, in form of the dextrorotatory (R)-(+)- enantiomer, is an irreversible inhibitor of carnitine palmitoyltransferase …
The CPT1a inhibitor, etomoxir induces severe oxidative stress …
2018年4月19日 · Etomoxir (ETO) is a widely used small-molecule inhibitor of fatty acid oxidation (FAO) through its irreversible inhibitory effects on the carnitine palmitoyl-transferase 1a …
Etomoxir | 乙莫克舍 | CPT-1a 抑制剂 | PPARα 激动剂 | TargetMol
Etomoxir is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that inhibits fatty acid oxidation by inhibiting CPT-1a and inhibits palmitate oxidation in humans, rats, and guinea pigs. …
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Etomoxir: an old dog with new tricks - Journal of Lipid Research
2024年7月31日 · Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of beta-oxidation
Etomoxir Inhibits Macrophage Polarization by Disrupting CoA …
Etomoxir is a small molecule developed for metabolic and cardiovascular disease that exhibits nanomolar potency toward CPT-1a and CPT-1b upon enzymatic conversion to the active …
Etomoxir - an overview | ScienceDirect Topics
Etomoxir is an inhibitor of carnitine palmitoyltransferase I initially developed as an antidiabetic agent. There is now increasing interest in the role of energy substrate switching in heart …
<br>鉴定 etomoxir 的脱靶效应表明，肉碱棕榈酰 ... - X-MOL
药理学抑制 FAO 超过 90% 的努力表明，高浓度的 etomoxir （200 μM） 具有抑制电子传递链复合物 I 的脱靶作用。 然而，令人惊讶的是，当 CPT1 的基因敲低进一步降低 FAO 时，这些相同 …
Etomoxir, a carnitine palmitoyltransferase 1 inhibitor, combined …
ETO, an FAO inhibitor, causes a lethal energy reduction in the GBM TSs. When used in combination with TMZ, ETO effectively reduces GBM cell stemness and invasiveness and …
Etomoxir | 124083-20-1 | AbMole | (R)-(+)-Etomoxir
Etomoxir（乙莫克舍）是一种有效的肉毒碱棕榈酰基转移酶 (CPT-1) 抑制剂，通过对长链脂肪酸氧化(LC-FAO)的限速酶CPT-1a的抑制，可导致脂质积聚，降低ATP和NADPH水平，从而抑制 …